Evidence map›Paper›PMID 31844755›Full record

ArticleHeliyon2019

Modulatory effects of ghrelin on sperm quality alterations induced by a fructose-enriched diet.

Nicolás David Ramírez, Eugenia Mercedes Luque, Xaviar Michael Jones, Pedro Javier Torres, María José Moreira Espinoza, Verónica Cantarelli, Marina Flavia Ponzio, Ana Arja, María Belén Rabaglino, Ana Carolina Martini

Open access · goldAbstract read
In one paragraph

Article in Heliyon, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Potentiality of ghrelin as antioxidant and protective agent.Redox report : communications in free radical research · 2021
    Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Nicolás David RamírezInstituto de Fisiología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Santa Rosa 1085, X5000ESU, Córdoba, Argentina.
Eugenia Mercedes LuqueInstituto de Fisiología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Santa Rosa 1085, X5000ESU, Córdoba, Argentina.
Xaviar Michael JonesInstituto de Fisiología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Santa Rosa 1085, X5000ESU, Córdoba, Argentina.
Pedro Javier TorresInstituto de Fisiología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Santa Rosa 1085, X5000ESU, Córdoba, Argentina.
María José Moreira EspinozaInstituto de Biología Celular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Enrique Barros esq, Enfermera Gordillo, Ciudad Universitaria, 5016, Córdoba, Argentina.
Verónica CantarelliInstituto de Fisiología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Santa Rosa 1085, X5000ESU, Córdoba, Argentina.
Marina Flavia PonzioInstituto de Fisiología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Santa Rosa 1085, X5000ESU, Córdoba, Argentina.
Ana ArjaInstituto de Fisiología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Santa Rosa 1085, X5000ESU, Córdoba, Argentina.
María Belén RabaglinoInstituto de Investigaciones en Ciencias de la Salud (INICSA), CONICET-Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Enrique Barros esq, Enfermera Gordillo, Pabellón de Biología Celular, Ciudad Universitaria, 5016, Córdoba, Argentina.
Ana Carolina MartiniInstituto de Fisiología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Santa Rosa 1085, X5000ESU, Córdoba, Argentina.
Universidad Nacional de Córdoba · ARConsejo Nacional de Investigaciones Científicas y Técnicas · ARInstituto de Investigaciones en Ciencias de la Salud · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objectives of this study were: 1) to evaluate the effects of a fructose enriched diet (FED) on rat sperm quality, epididymal function (i.e. oxidative stress and alpha-glucosidase expression) and testosterone concentrations; 2) to determine if the administration of ghrelin (Ghrl), reverses the effects induced by FED. After validating the protocol as an inductor of metabolic syndrome like-symptoms, adult male rats were assigned to one of the following treatments for 8 weeks: FED = 10% fructose enriched in water (v/v); FED + Ghrl = fructose enriched diet plus Ghrl (6 nmol/animal/day, s.c.) from week 6-8; or C = water without fructose (n = 5-10 animals/group). FED significantly decreased sperm concentration and motile sperm count/ml vs C (FED: 19.0 ± 1.6 × 10

Indexed as

Cell biologyDevelopmental biologyDietEndocrinologyEpididymisGlutathione peroxidaseMetabolic syndromeMolecular biologyNeutral alpha-glucosidaseOxidative stress

Identifiers

PMID31844755
PMCPMC6895644
OpenAlexW2991241731

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.