Evidence map›Paper›PMID 31844747›Full record

ArticleHeliyon2019

A chronic high-fat diet causes sperm head alterations in C57BL/6J mice.

A Funes, T E Saez Lancellotti, L D Santillan, M C Della Vedova, M A Monclus, M E Cabrillana, S E Gomez Mejiba, D C Ramirez, M W Fornes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Metabolic syndrome and male fertility disorders: Is there a causal link?Reviews in endocrine & metabolic disorders · 2021
    Review
  6. Heliyon · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

A FunesLIAM, Andrology Research Laboratory from Mendoza, IHEM-CCT-CONICET, National University of Cuyo and University of Aconcagua, Mendoza, 5500, Argentina.
T E Saez LancellottiLIAM, Andrology Research Laboratory from Mendoza, IHEM-CCT-CONICET, National University of Cuyo and University of Aconcagua, Mendoza, 5500, Argentina.
L D SantillanLETM, Laboratory of Experimental and Translational Medicine, IMIBIO-SL, CONICET, National University of San Luis, San Luis, 5700, Argentina.
M C Della VedovaLETM, Laboratory of Experimental and Translational Medicine, IMIBIO-SL, CONICET, National University of San Luis, San Luis, 5700, Argentina.
M A MonclusLIAM, Andrology Research Laboratory from Mendoza, IHEM-CCT-CONICET, National University of Cuyo and University of Aconcagua, Mendoza, 5500, Argentina.
M E CabrillanaLIAM, Andrology Research Laboratory from Mendoza, IHEM-CCT-CONICET, National University of Cuyo and University of Aconcagua, Mendoza, 5500, Argentina.
S E Gomez MejibaLET, Laboratory of Experimental Therapeutics, IMIBIO-SL, CONICET, National University of San Luis, San Luis, 5700, Argentina.
D C RamirezLETM, Laboratory of Experimental and Translational Medicine, IMIBIO-SL, CONICET, National University of San Luis, San Luis, 5700, Argentina.
M W FornesLIAM, Andrology Research Laboratory from Mendoza, IHEM-CCT-CONICET, National University of Cuyo and University of Aconcagua, Mendoza, 5500, Argentina.
Consejo Nacional de Investigaciones Científicas y Técnicas · ARNational University of San Luis · ARUniversidad Nacional de Cuyo · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A chronic-positive energetic balance has been directly correlated with infertility in men, but the involved mechanisms remain unknown. Herein we investigated weather in a mouse model a chronic feeding with a diet supplemented with chicken fat affects sperm head morphology. To accomplish this, we fed mice for 16 weeks with either control food (low-fat diet, LFD) or control food supplemented with 22% chicken fat (high-fat diet, HFD). At the end of the feeding regimen, we measured: redox and inflammatory changes, cholesterol accumulation in testis and analyzed testicular morphological structure and ultra-structure and liver morphology. We found that the mice fed HFD resembled some features of the human metabolic syndrome, including systemic oxidative stress and inflammation, this group showed an increment in the following parameters; central adiposity (adiposity index: 1.07 ± 0.10

Indexed as

Cell biologyDietDietary fatImmunologyInflammationMale fertilityMolecular biologyMouse modelOxidative stressProteinsSperm-head morphology

Identifiers

PMID31844747
PMCPMC6895587
OpenAlexW2990575912

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.