Evidence map›Paper›PMID 31844607›Full record

ArticleCurrent opinion in chemical engineering2019

Hybrid hydrogels for biomedical applications.

Luisa L Palmese, Raj Kumar Thapa, Millicent O Sullivan, Kristi L Kiick

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current opinion in chemical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed.

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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Luisa L PalmeseDepartment of Materials Science and Engineering, University of Delaware, Newark, DE 19716.
Raj Kumar ThapaDepartment of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716.
Millicent O SullivanDepartment of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716.
Kristi L KiickDepartment of Materials Science and Engineering, University of Delaware, Newark, DE 19716.

Funding

Pilot Research Subproject ProgramP30GM110758 · NIGMS · UNIVERSITY OF DELAWARE · PI POLENOVA, TATYANA · 2014 to 2018
$5.8M
Highly resilient, hydrophilic bioelastomers for engineering vocal fold tissueR01DC011377 · NIDCD · UNIVERSITY OF DELAWARE · PI KIICK, KRISTI L · 2012 to 2016
$2.3M
Collagen turnover-stimulated gene delivery to enhance chronic wound repairR01AR067247 · NIAMS · UNIVERSITY OF DELAWARE · PI KIICK, KRISTI L, MARGOLIS, DAVID · 2016 to 2019
$1.4M
Acquisition of a Zeiss LSM710 Confocal MicroscopeS10RR027273 · NCRR · UNIVERSITY OF DELAWARE · PI DUNCAN, MELINDA K · 2010 to 2010
$494k
Zeiss LSM710 Inverted Confocal MicroscopeS10OD016361 · OD · UNIVERSITY OF DELAWARE · PI CAPLAN, JEFFREY L · 2015 to 2015
$444k
NCRR NIH HHS S10 RR027273NIAMS NIH HHS R01 AR067247NIDCD NIH HHS R01 DC011377NIGMS NIH HHS P30 GM110758NIH HHS S10 OD016361
6 · The paper itself

Abstract

The use of hydrogels in biomedical applications dates back multiple decades, and the engineering potential of these materials continues to grow with discoveries in chemistry and biology. The approaches have led to increasing complex hydrogels that incorporate both synthetic and natural polymers and functional domains for tunable release kinetics, mediated cell response, and ultimately use in clinical and research applications in biomedical practice. This review focuses on recent advances in hybrid hydrogels that incorporate nano/microstructures, their synthesis, and applications in biomedical research. Examples discussed include the implementation of click reactions, photopatterning, and 3D printing for the facile production of these hybrid hydrogels, the use of biological molecules and motifs to promote a desired cellular outcome, and the tailoring of kinetic and transport behavior through hybrid-hydrogel engineering to achieve desired biomedical outcomes. Recent progress in the field has established promising approaches for the development of biologically relevant hybrid hydrogel materials with potential applications in drug discovery, drug/gene delivery, and regenerative medicine.

Indexed as

Biomedical applicationdrug/gene deliveryhybrid hydrogelmicrostructurenanostructureregenerative medicine

Identifiers

PMID31844607
PMCPMC6914224

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.