Evidence map›Paper›PMID 31844556›Full record

ArticleCancers of the head & neck2019

Genomic and human papillomavirus profiling of an oral cancer cohort identifies TP53 as a predictor of overall survival.

Neil Mundi, Stephenie D Prokopec, Farhad Ghasemi, Andrew Warner, Krupal Patel, Danielle MacNeil, Christopher Howlett, William Stecho, Paul Plantinga, Nicole Pinto and 12 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers of the head & neck, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Frontiers in oncology · 2021
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 3 institutions in 2 countries.

Neil Mundi1Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON Canada.ORCID 0000-0001-9328-8266
Stephenie D Prokopec3Ontario Institute for Cancer Research, Toronto, ON Canada.
Farhad Ghasemi1Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON Canada.
Andrew Warner4Department of Oncology, Western University, London, ON Canada.
Krupal Patel1Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON Canada.
Danielle MacNeil1Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON Canada.
Christopher Howlett5Department of Pathology, Western University, London, ON Canada.
William Stecho5Department of Pathology, Western University, London, ON Canada.
Paul Plantinga5Department of Pathology, Western University, London, ON Canada.
Nicole Pinto1Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON Canada.
Kara M Ruicci1Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON Canada.
Mohammed Imran Khan1Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON Canada.
Myung Woul Han6Department of Otolaryngology, College of Medicine, Ulsan University Hospital, University of Ulsan, Ulsan, South Korea.
John Yoo1Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON Canada.
Kevin Fung1Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON Canada.
Axel Sahovaler1Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON Canada.
David A Palma4Department of Oncology, Western University, London, ON Canada.
Eric Winquist4Department of Oncology, Western University, London, ON Canada.
Joe S Mymryk1Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON Canada.
John W Barrett1Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON Canada.
Paul C Boutros *3Ontario Institute for Cancer Research, Toronto, ON Canada.
Anthony C Nichols *1Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON Canada.
Western University · CAOntario Institute for Cancer Research · CAUniversity of Ulsan · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe genomic landscape of head and neck cancer has been reported through The Cancer Genome Atlas project. We attempt to determine if high-risk human papillomavirus (HPV) or frequently mutated genes are correlated with survival in an oral cancer cohort.

methodsPatient demographic data along with data from final pathology was collected. Tumor DNA was analyzed using a custom Illumina targeted sequencing panel. Five high-risk HPV types were tested by qPCR. Statistical analyses were used to identify associations between patient outcome and mutational status.

resultsHigh-risk HPV types were identified in 7% of cases; HPV status was not associated with survival. Mutations were identified in TP53, TERT promoter, & PIK3CA. Mutations in TP53 were significantly associated with poorer overall survival on multi-variate analysis (

conclusionsMutations in TP53 were associated with poor patient survival. Expanding our sample size may identify further predictors of outcome to direct customized cancer care.

Indexed as

GenomicsMutational statusOral cancerSurvivaltp53

Identifiers

PMID31844556
PMCPMC6894507
OpenAlexW2993552927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.