ArticleNature genetics2020
N
Open access · greenAbstract read
In one paragraph
Article in Nature genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
147citing papers in PubMed, 3 pooled it
11.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
147 citing papers in PubMed, 3 syntheses or guidelines pooled it, 263 citations in OpenAlex.
- The role of R-loops-mediated epigenetic regulation in genome stability maintenance and disease pathogenesis: a systematic review.Epigenetics · 2026Pooled it
- Quality-controlled R-loop meta-analysis reveals the characteristics of R-loop consensus regions.Nucleic acids research · 2022Pooled it
- Disrupting Mechanisms that Regulate Genomic Repeat Elements to Combat Cancer and Drug Resistance.Frontiers in cell and developmental biology · 2022Pooled it
- Decoding chromatin-associated RNA (caRNA) interaction networks: from genome-wide dynamic capture to epigenetic mechanisms in plants and animals.Epigenetics · 2026Review
- SEC Mediates mAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Chromosomal instability in cancer: sources, consequences and new therapeutic opportunities.Signal transduction and targeted therapy · 2026Review
- R-Loop Modification and Quantification by Dot Blot.Bio-protocol · 2026Article
- The role of non-coding RNAs in regulating R-loop dynamics in cancer: Mechanisms and therapeutic implications.Acta pharmaceutica Sinica. B · 2026Review
- R-loops and D-loops: a delicate balance in genomic stability and instability.Cell communication and signaling : CCS · 2026Review
- Review
- NAT10-dependent NCell reports · 2026Article
- Hypoxia-induced circSPECC1 drives temozolomide resistance in glioblastoma via IGF2BP2-mediated PGK1 mRNA stabilization.Cell death & disease · 2026Article
- Engineered targeted enhancement of translation in mammalian cell.BMC biology · 2026Article
- YTHDC1 recognizes METTL16-dependent mProceedings of the National Academy of Sciences of the United States of America · 2026Article
- DGCR8 regulates multiple processes of transcription coupled nucleotide excision repair.Scientific reports · 2026Article
- Crosstalk Between R-Loops, RNA/DNA Modifications, and Cell Death Dynamics in Canine Models of Retinitis Pigmentosa.Investigative ophthalmology & visual science · 2026Article
- p53 status determines the epigenetic response to demethylating agents azacitidine and decitabine.EMBO reports · 2026Article
- N(6)-methyladenosine modification of RNA is regulated by senataxin and E6 to control HPV replication.Cell reports · 2026Article
- RNA modification systems as therapeutic targets.Nature reviews. Drug discovery · 2026Review
- Hesperidin reduces genomic instability in glioblastoma cells and is associated with reduced HNRNPA2B1/mFrontiers in pharmacology · 2026Article
87 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on bym2020
Authors and funding
22 authors at 6 institutions in 4 countries.
Abdulkadir AbakirDepartment of Stem Cell Biology, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0001-5043-5529
Tom C GilesAdvanced Data Analysis Centre, University of Nottingham, Sutton Bonington, UK.
Agnese CristiniSir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Jeremy M FosterNew England Biolabs, Inc., Ipswich, MA, USA.ORCID http://orcid.org/0000-0001-5107-6513
Nan DaiNew England Biolabs, Inc., Ipswich, MA, USA.
Marta StarczakDepartment of Clinical Biochemistry, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland.
Alejandro Rubio-RoldanGENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, Granada, Spain.
Miaomiao LiDepartment of Microbiology, Oslo University Hospital, Oslo, Norway.
Maria EleftheriouDepartment of Stem Cell Biology, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0002-1842-5838
James CrutchleyDepartment of Stem Cell Biology, University of Nottingham, Nottingham, UK.
Luke FlattDepartment of Stem Cell Biology, University of Nottingham, Nottingham, UK.
Lorraine YoungDepartment of Stem Cell Biology, University of Nottingham, Nottingham, UK.
Daniel J GaffneyWellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-1529-1862
Chris DenningDepartment of Stem Cell Biology, University of Nottingham, Nottingham, UK.
Bjørn DalhusDepartment of Microbiology, Oslo University Hospital, Oslo, Norway.
Richard D EmesAdvanced Data Analysis Centre, University of Nottingham, Sutton Bonington, UK.ORCID http://orcid.org/0000-0001-6855-5481
Daniel GackowskiDepartment of Clinical Biochemistry, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland.ORCID http://orcid.org/0000-0002-7259-1511
Ivan R CorrêaNew England Biolabs, Inc., Ipswich, MA, USA.ORCID http://orcid.org/0000-0002-3169-6878
Jose L Garcia-PerezGENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, Granada, Spain.ORCID http://orcid.org/0000-0002-8132-9849
Arne KlunglandDepartment of Microbiology, Oslo University Hospital, Oslo, Norway. arne.klungland@medisin.uio.no.ORCID http://orcid.org/0000-0001-7274-3661
Natalia GromakSir William Dunn School of Pathology, University of Oxford, Oxford, UK. natalia.gromak@path.ox.ac.uk.
Alexey RuzovDepartment of Stem Cell Biology, University of Nottingham, Nottingham, UK. alexey.ruzov@nottingham.ac.uk.ORCID http://orcid.org/0000-0002-1247-6634
University of Nottingham · GBOslo University Hospital · NONicolaus Copernicus University · PLPfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research · ESUniversity of Oxford · GBWellcome Sanger Institute · GB
Funding
Biotechnology and Biological Sciences Research Council BB/M012336/1Biotechnology and Biological Sciences Research Council BB/N005759/1British Heart Foundation PG/14/59/31000British Heart Foundation SP/15/9/31605Medical Research Council 1792340Medical Research Council MR/J007870/1Medical Research Council MR/M017354/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/C013105/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/C013202/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/K000225/1Wellcome Trust
Abstract
R-loops are nucleic acid structures formed by an RNA:DNA hybrid and unpaired single-stranded DNA that represent a source of genomic instability in mammalian cells
Indexed as
Genomic InstabilityAdenosineAnimalsDNADNA DamageHumansMiceMice, KnockoutMitosisPluripotent Stem CellsRNARNA-Binding ProteinsRNA, MessengerRNA StabilityAdenosineDNAN-methyladenosineRNARNA-Binding ProteinsRNA, MessengerYTHDF2 protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.