ArticleNature genetics2020
Loss of ADAMTS19 causes progressive non-syndromic heart valve disease.
Open access · greenAbstract read
In one paragraph
Article in Nature genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Genomic Landscape and Mutational Spectrum of ADAMTS Family Genes in Mendelian Disorders Based on Gene Evidence Review for Variant Interpretation.Biomolecules · 2020Pooled it
- Review
- Transcriptional dynamics of the murine heart during perinatal development at single-cell resolution.Biology open · 2026Article
- ADAM and ADAMTS proteases as integrative hubs in heart failure pathogenesis and therapy.iScience · 2026Review
- Organ-Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Rare regulatory mutations disrupt mesenchymal molecular programs driving endocardial cushion formation in bicuspid aortic valve.Nature communications · 2026Article
- Novel compound heterozygous variants in theFrontiers in cardiovascular medicine · 2026Article
- ADAMTS5 Orchestrates Cell Lineage Specific Patterning and Extracellular Matrix Organization During Semilunar Valve Development.Journal of cardiovascular development and disease · 2025Article
- Implications of monogenic bicuspid aortic valve (BAV) forms among sporadic BAV patients.European journal of human genetics : EJHG · 2025Article
- Genome-wide association studies of Alzheimer's disease and related disorders stratified by sex, onset age, and Apolipoprotein E genotype reveal novel risk loci in African Americans.Alzheimer's research & therapy · 2025Article
- Navigating the Landscape of Translational Medicine of Calcific Aortic Valve Disease: Bridging Bench to Bedside.JACC. Asia · 2025Review
- ProteinMolecules (Basel, Switzerland) · 2025Review
- ADAMTS4 exacerbates lung cancer progression via regulating c-Myc protein stability and activating MAPK signaling pathway.Biology direct · 2024Article
- Cells and Molecules Underpinning Cannabis-Related Variations in Cortical Thickness during Adolescence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Mitral valve transcriptome analysis in thirty-four age-matched Cavalier King Charles Spaniels with or without congestive heart failure caused by myxomatous mitral valve disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Article
- Valvular heart disease and cardiomyopathy: reappraisal of their interplay.Nature reviews. Cardiology · 2024Review
- Degenerative mitral regurgitation.Nature reviews. Disease primers · 2023Review
- PROX1 Inhibits PDGF-B Expression to Prevent Myxomatous Degeneration of Heart Valves.Circulation research · 2023Article
- The Role of ADAMTS Proteoglycanases in Thoracic Aortic Disease.International journal of molecular sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 17 institutions in 8 countries.
Florian Wünnemann *Cardiovascular Genetics, Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine Research Centre, University of Montreal, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0002-0978-6076
Asaf Ta-Shma *Department of Pediatric Cardiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.ORCID http://orcid.org/0000-0003-0076-9568
Christoph PreussThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID http://orcid.org/0000-0003-1039-6080
Severine LeclercCardiovascular Genetics, Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine Research Centre, University of Montreal, Montreal, Quebec, Canada.
Patrick Piet van VlietCardiovascular Genetics, Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine Research Centre, University of Montreal, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0002-1986-5835
Andrea OnegliaCardiovascular Genetics, Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine Research Centre, University of Montreal, Montreal, Quebec, Canada.
Maryse ThibeaultCardiovascular Genetics, Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine Research Centre, University of Montreal, Montreal, Quebec, Canada.
Emily NordquistMolecular, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH, USA.
Joy LincolnDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
Franka ScharfenbergUnit for Degradomics of the Protease Web, Institute of Biochemistry, University of Kiel, Kiel, Germany.
Christoph Becker-PaulyUnit for Degradomics of the Protease Web, Institute of Biochemistry, University of Kiel, Kiel, Germany.
Philipp HofmannDepartment of Congenital Heart Disease and Pediatric Cardiology, University Hospital Schleswig-Holstein, Kiel, Germany.
Kirstin HoffDepartment of Congenital Heart Disease and Pediatric Cardiology, University Hospital Schleswig-Holstein, Kiel, Germany.
Enrique AudainDepartment of Congenital Heart Disease and Pediatric Cardiology, University Hospital Schleswig-Holstein, Kiel, Germany.ORCID http://orcid.org/0000-0002-9201-7840
Hans-Heiner KramerDepartment of Congenital Heart Disease and Pediatric Cardiology, University Hospital Schleswig-Holstein, Kiel, Germany.
Wojciech MakalowskiInstitute of Bioinformatics, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0003-2303-9541
Amiram NirDepartment of Pediatric Cardiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Sebastian S GeretyWellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-6126-5040
Matthew HurlesWellcome Sanger Institute, Cambridge, UK.
Johanna ComesCardiovascular Genetics, Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine Research Centre, University of Montreal, Montreal, Quebec, Canada.
Anne FournierDepartment of Pediatrics, University of Montreal, Montreal, Quebec, Canada.
Hanna OsinskaDivision of Molecular Cardiovascular Biology, Cincinnati Children's Hospital, Cincinnati, OH, USA.
Jeffrey RobinsDivision of Molecular Cardiovascular Biology, Cincinnati Children's Hospital, Cincinnati, OH, USA.
Michel PucéatLIA (International Associated Laboratory) Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0001-9055-7563
MIBAVA Leducq Consortium principal investigators
Orly ElpelegMonique and Jacques Robo Department of Genetic Research, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Marc-Phillip HitzDepartment of Congenital Heart Disease and Pediatric Cardiology, University Hospital Schleswig-Holstein, Kiel, Germany.ORCID http://orcid.org/0000-0001-9894-6897
Gregor Andelfinger *Cardiovascular Genetics, Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine Research Centre, University of Montreal, Montreal, Quebec, Canada. gregor.andelfinger@recherche-ste-justine.qc.ca.ORCID http://orcid.org/0000-0002-9047-0502
Centre Hospitalier Universitaire Sainte-Justine · CAUniversity Hospital Schleswig-Holstein · DEHadassah Medical Center · ILWellcome Sanger Institute · GBChristian-Albrechts-Universität zu Kiel · DECincinnati Children's Hospital Medical Center · USInserm · FRJohns Hopkins University · USKarolinska University Hospital · SEUniversity of Antwerp · BEUniversity of Münster · DEChildren's Hospital of Wisconsin · USHospital for Sick Children · CAJackson Laboratory · USMedical College of Wisconsin · USUniversité de Montréal · CAUniversity of Toronto · CA
Funding
Training To Provide the Knowledge, Skills, and Culture To the Next Generation of Cardiovascular ScientistsT32HL134616 · NHLBI · OHIO STATE UNIVERSITY · PI Brandon J Biesiadecki, Jill A Rafael-Fortney · 2017 to 2026
$2.6MNHLBI NIH HHS T32 HL134616Wellcome TrustWellcome Trust (Wellcome) WT098051
Abstract
Valvular heart disease is observed in approximately 2% of the general population
Indexed as
Gene Expression Regulation, DevelopmentalADAMTS ProteinsAnimalsFamilyFemaleHeart Valve DiseasesHumansKruppel-Like Transcription FactorsMaleMiceMice, KnockoutPedigreeSingle-Cell AnalysisWnt Signaling PathwayADAMTS19 protein, humanAdamts2 protein, mouseADAMTS ProteinsKLF2 protein, humanKlf2 protein, mouseKruppel-Like Transcription Factors
Identifiers
What OpenQuestion holds
Textmetadata
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.