ArticleNature neuroscience2020
Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 93 papers.
0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
93 citing papers in PubMed, 179 citations in OpenAlex.
- Astrocytes mediate the dopaminergic modulation of tonic GABAergic signaling in substantia nigra.Science advances · 2026Article
- Brain mitochondria as key drivers of cognition and behaviour.Nature reviews. Neuroscience · 2026Review
- Chronic Methamphetamine Administration Increases Mitochondrial Density and Impairs Mitochondrial Function in the Substantia Nigra Pars Compacta.Journal of neurochemistry · 2026Article
- Sexual dimorphism of midbrain catecholaminergic metabolism revealed by neuromelanin-sensitive MRI.Molecular psychiatry · 2026Article
- The Diagnostic and Therapeutic Value of Micro-RNA in Parkinson's Disease.Cellular and molecular neurobiology · 2026Review
- Dopamine-Derived Oxidative Stress in Attention-Deficit/Hyperactivity Disorder: A Narrative Review of Molecular Mechanisms, Neural Circuitry, and Therapeutic Implications.Antioxidants (Basel, Switzerland) · 2026Review
- Nootkatone confers MAOB-dependent neuroprotection against ferroptotic injury via brain-targeted nanoparticle delivery in ischemic stroke.Journal of nanobiotechnology · 2026Article
- Compartment-Specific Mitochondrial Proteomic Alterations in Rat Hippocampus Following Chronic Social Isolation Stress.International journal of molecular sciences · 2026Review
- Decreased Length of Locus Coeruleus Norepinephrine Axons and Increased Amyloid Beta Pathology in Male APP/PS1 Mice During Protracted Abstinence From Alcohol.Neurotoxicity research · 2026Article
- Dual-Emission Fluorescent Probe for Simultaneous Visualization of Monoamine Oxidase A and Lysyl Oxidase in Alzheimer's Disease Cell Models.Chemical & biomedical imaging · 2026Article
- Synergism of IP3R and Parkin mutants identifies mitochondrial stress as an early feature of Parkinson's disease.Disease models & mechanisms · 2026Article
- Article
- Effect of Functional Electrical Stimulation Combined With Physical Exercise on Electron Transport Chain Activity in Peripheral Blood Cells of Stroke Patients.Artificial organs · 2025Article
- Dysregulated circRNA-miRNA-mRNA networks reveal stage-specific mRNA expression changes in Parkinson's disease.Molecular brain · 2025Article
- The allostatic triage model of psychopathology (ATP Model): How reallocation of brain energetic resources under stress elicits psychiatric symptoms.Neuroscience and biobehavioral reviews · 2025Review
- Remolding laccase for whole-cell and in vivo modulation of dopamine signal.Science advances · 2025Article
- Review
- Dehydrogenases in the Flavoprotein Amine Oxidoreductase Superfamily.Biochemistry · 2025Article
- Human placental extract rescues hippocampal damage associated with cognitive impairment in diabetic male rats through antioxidative, anti-inflammatory, and neuromodulatory activities.Metabolic brain disease · 2025Article
- Mechanism and application of thiol-disulfide redox biosensors with a fluorescence-lifetime readout.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
14 authors at 4 institutions in 1 country.
Steven M GravesDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Zhong XieDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-8348-4455
Kristen A StoutDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Enrico ZampeseDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-8851-2566
Lena F BurbullaDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Jean C ShihDepartment of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, USA.
Jyothisri KondapalliDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Tommaso PatriarchiDepartment of Biochemistry and Molecular Medicine, School of Medicine, University of California-Davis Davis, Davis, CA, USA.
Lin TianDepartment of Biochemistry and Molecular Medicine, School of Medicine, University of California-Davis Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0001-7012-6926
Lars BrichtaLaboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY, USA.
Paul GreengardLaboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0002-4437-0893
Dimitri KraincDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Paul T SchumackerDepartment of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
D James SurmeierDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. j-surmeier@northwestern.edu.ORCID http://orcid.org/0000-0002-6376-5225
Northwestern University · USRockefeller University · USUniversity of California, Davis · USUniversity of Southern California · US
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9MSYNAPTIC CONTROLOF PALLIDAL ACTIVITYP50NS047085 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SURMEIER, DALTON JAMES · 2003 to 2018
$19.2MDopaminergic and Muscarinic Signaling in the StriatumR01NS034696 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SURMEIER, DALTON JAMES · 1996 to 2018
$4.3MThe Role of Lysosomal Glucocerebrosidase in SynucleinopathiesR01NS076054 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KRAINC, DIMITRI · 2011 to 2020
$4.1MGenetically encoded indicators for large-scale sensing of neuromodulatory signaling in behaving animalsU01NS103522 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NIMMERJAHN, AXEL, TIAN, LIN · 2017 to 2019
$2.9MGenetically encoded sensors for the biogenic amine: watching neuromodulation in actionU01NS090604 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TIAN, LIN · 2014 to 2016
$1.3MMethamphetamine and Parkinson's disease: converging mechanisms of pathogenesisR00DA039253 · NIDA · UNIVERSITY OF MINNESOTA · PI GRAVES, STEVEN MICHAEL · 2018 to 2020
$747kMethamphetamine and Parkinson's disease: converging mechanisms of pathogenesisK99DA039253 · NIDA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GRAVES, STEVEN MICHAEL · 2016 to 2017
$274kNCI NIH HHS P30 CA060553NIDA NIH HHS K99 DA039253NIDA NIH HHS R00 DA039253NINDS NIH HHS P50 NS047085NINDS NIH HHS R01 NS034696NINDS NIH HHS R01 NS076054NINDS NIH HHS U01 NS090604NINDS NIH HHS U01 NS103522U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) U01NS090604U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) U01NS103522
Abstract
Monoamine oxidase (MAO) metabolizes cytosolic dopamine (DA), thereby limiting auto-oxidation, but is also thought to generate cytosolic hydrogen peroxide (H
Indexed as
AnimalsDopamineDopaminergic NeuronsElectron TransportEnergy MetabolismHumansMaleMiceMice, Inbred C57BLMice, KnockoutMitochondriaMonoamine OxidaseOxidation-ReductionDopamineMonoamine Oxidase
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.