ArticleNature microbiology2020
The structure of the periplasmic FlaG-FlaF complex and its essential role for archaellar swimming motility.
Article in Nature microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Review
- Sulfolobales: Acidothermophilic archaea as models for biology and biotechnological applications.Engineering microbiology · 2026Review
- CsmR controls both, motility and cell shape, in Haloferax volcanii.PLoS genetics · 2026Article
- A multilayered cell envelope of a member of the Chloroflexota offers an anchoring platform for the archaellum.Frontiers in microbiology · 2026Article
- Structure of a functional archaellum in Bacteria of the Chloroflexota phylum.Nature microbiology · 2025Article
- Cyclization of archaeal membrane lipids impacts membrane protein activity and archaellum formation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- An unusual glycerol-3-phosphate dehydrogenase in Sulfolobus acidocaldarius elucidates the diversity of glycerol metabolism across Archaea.Communications biology · 2025Article
- How Does the Archaellum Work?Biomolecules · 2025Review
- Unusual cell surfaces, pili, and archaella of Thermoplasmatales archaea.The ISME journal · 2025Article
- Towards a molecular picture of the archaeal cell surface.Nature communications · 2024Article
- Involvement of ArlI, ArlJ, and CirA in archaeal type IV pilin-mediated motility regulation.Journal of bacteriology · 2024Article
- Adhesion pilus retraction powers twitching motility in the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius.Nature communications · 2024Article
- Involvement of ArlI, ArlJ, and CirA in Archaeal Type-IV Pilin-Mediated Motility Regulation.bioRxiv : the preprint server for biology · 2024Article
- The evolution of archaeal flagellar filaments.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Direct Observation of Archaellar Motor Rotation by Single-Molecular Imaging Techniques.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Membrane lipid and expression responses ofFrontiers in microbiology · 2023Article
- Disentangling a metabolic cross-feeding in a halophilic archaea-bacteria consortium.Frontiers in microbiology · 2023Article
- Electron cryo-microscopy reveals the structure of the archaeal thread filament.Nature communications · 2022Article
- Comparative Genomic Insights into Chemoreceptor Diversity and Habitat Adaptation of Archaea.Applied and environmental microbiology · 2022Article
- The cell biology of archaea.Nature microbiology · 2022Review
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Authors and funding
12 authors.
Funding
Abstract
Motility structures are vital in all three domains of life. In Archaea, motility is mediated by the archaellum, a rotating type IV pilus-like structure that is a unique nanomachine for swimming motility in nature. Whereas periplasmic FlaF binds the surface layer (S-layer), the structure, assembly and roles of other periplasmic components remain enigmatic, limiting our knowledge of the archaellum's functional interactions. Here, we find that the periplasmic protein FlaG and the association with its paralogue FlaF are essential for archaellation and motility. Therefore, we determine the crystal structure of Sulfolobus acidocaldarius soluble FlaG (sFlaG), which reveals a β-sandwich fold resembling the S-layer-interacting FlaF soluble domain (sFlaF). Furthermore, we solve the sFlaG
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