Evidence map›Paper›PMID 31844288›Full record

ArticleNature nanotechnology2020

Artificial water channels enable fast and selective water permeation through water-wire networks.

Woochul Song, Himanshu Joshi, Ratul Chowdhury, Joseph S Najem, Yue-Xiao Shen, Chao Lang, Codey B Henderson, Yu-Ming Tu, Megan Farell, Megan E Pitz and 7 more

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Nature nanotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 167 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Highly Selective Bioinspired Peptide Channels for Rapid Water Transport.Angewandte Chemie (International ed. in English) · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Microbial membrane transport proteins and their biotechnological applications.World journal of microbiology & biotechnology · 2024
    Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. CHARMM-GUIJournal of chemical theory and computation · 2023
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Woochul SongDepartment of Chemical Engineering, The Pennsylvania State University, University Park, PA, USA.
Himanshu JoshiDepartment of Physics, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Ratul ChowdhuryDepartment of Chemical Engineering, The Pennsylvania State University, University Park, PA, USA.ORCID http://orcid.org/0000-0003-4522-6911
Joseph S NajemDepartment of Mechanical, Aerospace, and Biomedical Engineering, The University of Tennessee, Knoxville, TN, USA.
Yue-Xiao ShenDepartment of Civil, Environmental, & Construction Engineering, Texas Tech University, Lubbock, TX, USA.
Chao LangDepartment of Chemical Engineering, The Pennsylvania State University, University Park, PA, USA.
Codey B HendersonDepartment of Chemistry, The Pennsylvania State University, University Park, PA, USA.
Yu-Ming TuDepartment of Chemical Engineering, The Pennsylvania State University, University Park, PA, USA.
Megan FarellDepartment of Chemical Engineering, The Pennsylvania State University, University Park, PA, USA.
Megan E PitzDepartment of Mechanical, Aerospace, and Biomedical Engineering, The University of Tennessee, Knoxville, TN, USA.
Costas D MaranasDepartment of Chemical Engineering, The Pennsylvania State University, University Park, PA, USA.
Paul S CremerDepartment of Chemistry, The Pennsylvania State University, University Park, PA, USA.
Robert J HickeyDepartment of Materials Science and Engineering, The Pennsylvania State University, University Park, PA, USA.
Stephen A SarlesDepartment of Mechanical, Aerospace, and Biomedical Engineering, The University of Tennessee, Knoxville, TN, USA.
Jun-Li HouDepartment of Chemistry, Fudan University, Shanghai, China.
Aleksei AksimentievDepartment of Physics, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID http://orcid.org/0000-0002-6042-8442
Manish KumarDepartment of Chemical Engineering, The Pennsylvania State University, University Park, PA, USA. manish.kumar@utexas.edu.ORCID http://orcid.org/0000-0001-5545-3793
Pennsylvania State University · USUniversity of Illinois Urbana-Champaign · USUniversity of Tennessee at Knoxville · USFudan University · CNTexas Tech University · US

Funding

WHOLE CELL SIMULATIONP41GM104601 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI TAJKHORSHID, EMAD · 2012 to 2021
$19.0M
NIGMS NIH HHS P41 GM104601
6 · The paper itself

Abstract

Artificial water channels are synthetic molecules that aim to mimic the structural and functional features of biological water channels (aquaporins). Here we report on a cluster-forming organic nanoarchitecture, peptide-appended hybrid[4]arene (PAH[4]), as a new class of artificial water channels. Fluorescence experiments and simulations demonstrated that PAH[4]s can form, through lateral diffusion, clusters in lipid membranes that provide synergistic membrane-spanning paths for a rapid and selective water permeation through water-wire networks. Quantitative transport studies revealed that PAH[4]s can transport >10

Indexed as

AquaporinsCalixarenesMembranes, ArtificialMolecular Dynamics SimulationNanostructuresPeptidesPermeabilityPhenolsWaterAquaporinscalix(4)areneCalixarenesMembranes, ArtificialPeptidesPhenolsWater

Identifiers

PMID31844288
PMCPMC7008941
OpenAlexW2995921167

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.