Evidence map›Paper›PMID 31844278›Full record

ArticleNature materials2020

Biofuel powered glucose detection in bodily fluids with an n-type conjugated polymer.

David Ohayon, Georgios Nikiforidis, Achilleas Savva, Andrea Giugni, Shofarul Wustoni, Tamilarasan Palanisamy, Xingxing Chen, Iuliana Petruta Maria, Enzo Di Fabrizio, Pedro M F J Costa and 2 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Nature materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
15.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 283 citations in OpenAlex.

  1. Multiscale Manufacturing of Organic Electronic Materials.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
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  15. Single-Component Electroactive Polymer Architectures for Non-Enzymatic Glucose Sensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  16. Article
  17. Organic Electrochemical Transistors for Biomarker Detections.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  18. A Highly ConductiveJournal of the American Chemical Society · 2024
    Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

David Ohayon *Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Georgios Nikiforidis *Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Achilleas SavvaBiological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.ORCID http://orcid.org/0000-0002-0197-0290
Andrea GiugniPhysical Science and Engineering Division, KAUST, Thuwal, Saudi Arabia.ORCID http://orcid.org/0000-0003-2845-9828
Shofarul WustoniBiological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Tamilarasan PalanisamyPhysical Science and Engineering Division, KAUST, Thuwal, Saudi Arabia.
Xingxing ChenPhysical Science and Engineering Division, KAUST, Thuwal, Saudi Arabia.
Iuliana Petruta MariaDepartment of Chemistry and Centre for Plastic Electronics, Imperial College London, London, UK.
Enzo Di FabrizioPhysical Science and Engineering Division, KAUST, Thuwal, Saudi Arabia.
Pedro M F J CostaPhysical Science and Engineering Division, KAUST, Thuwal, Saudi Arabia.ORCID http://orcid.org/0000-0002-1993-6701
Iain McCullochPhysical Science and Engineering Division, KAUST, Thuwal, Saudi Arabia.
Sahika InalBiological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia. sahika.inal@kaust.edu.sa.ORCID http://orcid.org/0000-0002-1166-1512
King Abdullah University of Science and Technology · SAImperial College London · GBCentral Electrochemical Research Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A promising class of materials for applications that rely on electron transfer for signal generation are the n-type semiconducting polymers. Here we demonstrate the integration of an n-type conjugated polymer with a redox enzyme for the autonomous detection of glucose and power generation from bodily fluids. The reversible, mediator-free, miniaturized glucose sensor is an enzyme-coupled organic electrochemical transistor with a detection range of six orders of magnitude. This n-type polymer is also used as an anode and paired with a polymeric cathode in an enzymatic fuel cell to convert the chemical energy of glucose and oxygen into electrical power. The all-polymer biofuel cell shows a performance that scales with the glucose content in the solution and a stability that exceeds 30 days. Moreover, at physiologically relevant glucose concentrations and from fluids such as human saliva, it generates enough power to operate an organic electrochemical transistor, thus contributes to the technological advancement of self-powered micrometre-scale sensors and actuators that run on metabolites produced in the body.

Indexed as

Bioelectric Energy SourcesBiosensing TechniquesElectrochemical TechniquesGlucoseHumansSalivaGlucose

Identifiers

PMID31844278
OpenAlexW2996154224

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.