Evidence map›Paper›PMID 31844119›Full record

ArticleScientific reports2019

Characterization of the fecal microbiome in cats with inflammatory bowel disease or alimentary small cell lymphoma.

Sina Marsilio, Rachel Pilla, Benjamin Sarawichitr, Betty Chow, Steve L Hill, Mark R Ackermann, J Scot Estep, Jonathan A Lidbury, Joerg M Steiner, Jan S Suchodolski

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 100 citations in OpenAlex.

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  7. The Effects of DietaryAnimals : an open access journal from MDPI · 2026
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Sina MarsilioGastrointestinal Laboratory, Department of Small Animal Clinical Science, Texas A&M University, 4474 TAMU, College Station, TX, 77843-4474, USA. SMarsilio@ucdavis.edu.
Rachel PillaGastrointestinal Laboratory, Department of Small Animal Clinical Science, Texas A&M University, 4474 TAMU, College Station, TX, 77843-4474, USA.
Benjamin SarawichitrGastrointestinal Laboratory, Department of Small Animal Clinical Science, Texas A&M University, 4474 TAMU, College Station, TX, 77843-4474, USA.
Betty ChowVeterinary Specialty Hospital, 10435 Sorrento Valley Rd, San Diego, CA, 92121, USA.ORCID http://orcid.org/0000-0002-7775-3719
Steve L HillVeterinary Specialty Hospital, 10435 Sorrento Valley Rd, San Diego, CA, 92121, USA.
Mark R AckermannOregon Veterinary Diagnostic Laboratory, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA.
J Scot EstepTexas Veterinary Pathology, LLC, San Antonio, TX, USA.
Jonathan A LidburyGastrointestinal Laboratory, Department of Small Animal Clinical Science, Texas A&M University, 4474 TAMU, College Station, TX, 77843-4474, USA.
Joerg M SteinerGastrointestinal Laboratory, Department of Small Animal Clinical Science, Texas A&M University, 4474 TAMU, College Station, TX, 77843-4474, USA.
Jan S SuchodolskiGastrointestinal Laboratory, Department of Small Animal Clinical Science, Texas A&M University, 4474 TAMU, College Station, TX, 77843-4474, USA.
Texas A&M University · USOrthopedic Specialty Hospital · USOregon State University · USUniversity of California, Davis · US

Funding

HSRD VA IIR 16-018
6 · The paper itself

Abstract

Feline chronic enteropathy (CE) is a common gastrointestinal disorder in cats and mainly comprises inflammatory bowel disease (IBD) and small cell lymphoma (SCL). Both IBD and SCL in cats share features with chronic enteropathies such as IBD and monomorphic epitheliotropic intestinal T-cell lymphoma in humans. The aim of this study was to characterize the fecal microbiome of 38 healthy cats and 27 cats with CE (13 cats with IBD and 14 cats with SCL). Alpha diversity indices were significantly decreased in cats with CE (OTU p = 0.003, Shannon Index p = 0.008, Phylogenetic Diversity p = 0.019). ANOSIM showed a significant difference in bacterial communities, albeit with a small effect size (P = 0.023, R = 0.073). Univariate analysis and LEfSE showed a lower abundance of facultative anaerobic taxa of the phyla Firmicutes (families Ruminococcaceae and Turicibacteraceae), Actinobacteria (genus Bifidobacterium) and Bacteroidetes (i.a. Bacteroides plebeius) in cats with CE. The facultative anaerobic taxa Enterobacteriaceae and Streptococcaceae were increased in cats with CE. No significant difference between the microbiome of cats with IBD and those with SCL was found. Cats with CE showed patterns of dysbiosis similar to those in found people with IBD.

Indexed as

AnimalsBacteriaCat DiseasesCatsDigestive SystemDysbiosisFecesInflammatory Bowel DiseasesLeukemia, Lymphocytic, Chronic, B-CellMicrobiotaPhylogenyProspective Studies

Identifiers

PMID31844119
PMCPMC6914782
OpenAlexW2995055953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.