ArticleScientific reports2019
PEG grafted chitosan scaffold for dual growth factor delivery for enhanced wound healing.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 113 citations in OpenAlex.
- The role of nanoparticles in the treatment of diabetic foot ulcers: mechanisms, delivery platforms, translational challenges, and future directions.Discover nano · 2026Review
- Chitosan-Based Hydrogels in Vascular Tissue Engineering Applications.Materials (Basel, Switzerland) · 2026Review
- EGF-supplemented decellularized tracheal matrix hydrogels promote tracheal defect repair.Journal of cardiothoracic surgery · 2026Article
- Recent Advances and Applications of Chitin and Chitosan Hydrogel Scaffolds in Tissue Engineering.Gels (Basel, Switzerland) · 2026Review
- Efficacy of Platelet-Rich Plasma and Polyvinyl Alcohol Wound Dressing in Open Wound Healing: First Results from an Experimental Rat Model.European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes · 2026Article
- Erythropoietin in tissue engineering and beyond: a multifunctional macromolecule with emerging roles in organoids, immune modulation, and cancer research.Frontiers in bioengineering and biotechnology · 2026Review
- Synthetic Polymer-Based Interventions in Wound Healing: A Clinical Perspective on their Efficacy and Limitations.Current pharmaceutical design · 2026Review
- Evaluation of wound regeneration potential of nano-phytoextracts loaded carboxymethyl chitosan scaffolds for diabetic foot ulcer.Scientific reports · 2025Article
- Concomitant heparin use promotes skin graft donor site healing by basic fibroblast growth factor: A pilot prospective randomized controlled study.Contemporary clinical trials communications · 2024Article
- Stability, challenges, and prospects of chitosan for the delivery of anticancer drugs and tissue regenerative growth factors.Heliyon · 2024Review
- Article
- Water-powered, electronics-free dressings that electrically stimulate wounds for rapid wound closure.Science advances · 2024Article
- Tuning Mechanical Properties, Swelling, and Enzymatic Degradation of Chitosan Cryogels Using Diglycidyl Ethers of Glycols with Different Chain Length as Cross-Linkers.Gels (Basel, Switzerland) · 2024Article
- Strategies to enhance the efficacy of FGF2-based therapies for skin wound healing.Archives of dermatological research · 2024Review
- Growth factors and growth factor gene therapies for treating chronic wounds.Bioengineering & translational medicine · 2024Review
- Physicochemical Properties of Inorganic and Hybrid Hydroxyapatite-Based Granules Modified with Citric Acid or Polyethylene Glycol.Molecules (Basel, Switzerland) · 2024Article
- Auranofin-Loaded Chitosan Nanoparticles Demonstrate Potency against Triple-Negative Breast Cancer.ACS applied bio materials · 2024Article
- Chitosan nanoparticle applications in dentistry: a sustainable biopolymer.Frontiers in chemistry · 2024Review
- Piezoelectric and Triboelectric Nanogenerators for Enhanced Wound Healing.Biomimetics (Basel, Switzerland) · 2023Review
- Secured delivery of basic fibroblast growth factor using human serum albumin-based protein nanoparticles for enhanced wound healing and regeneration.Journal of nanobiotechnology · 2023Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Application of growth factors at wound site has improved the efficiency and quality of healing. Basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) induce proliferation of various cells in wound healing. Delivery of growth factor from controlled release systems protect it from degradation and also result in sustained delivery of it at the site of injury. The goal of the study was to develop a Polyethylene glycol (PEG) cross-linked cotton-like chitosan scaffold (CS-PEG-H) by freeze-drying method and chemically conjugate heparin to the scaffold to which the growth factors can be electrostatically bound and evaluate its wound healing properties in vitro and in vivo. The growth factor containing scaffolds induced increased proliferation of HaCaT cells, increased neovascularization and collagen formation seen by H and E and Masson's trichrome staining. Immunohistochemistry was performed using the Ki67 marker which increased proliferation of cells in growth factor containing scaffold treated group. Frequent dressing changes are a major deterrent to proper wound healing. Our system was found to release both VEGF and bFGF in a continuous manner and attained stability after 7 days. Thus our system can maintain therapeutic levels of growth factor at the wound bed thereby avoiding the need for daily applications and frequent dressing changes. Thus, it can be a promising candidate for wound healing.
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