ArticleNature communications2019
Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
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- Phenotypic tolerance for rDNA copy number variation within the natural range of C. elegans.PLoS genetics · 2025Article
- Heat tolerance and genetic adaptations in Caenorhabditis briggsae: insights from comparative studies with Caenorhabditis elegans.Genetics · 2025Article
- Beyond genes and environment: mapping biological stochasticity in aging.GeroScience · 2025Review
- Heterogeneity in maternal mRNAs within clutches of eggs in response to thermal stress during the embryonic stage.BMC ecology and evolution · 2024Article
- Butein Increases Resistance to Oxidative Stress and Lifespan with Positive Effects on the Risk of Age-Related Diseases inAntioxidants (Basel, Switzerland) · 2024Article
- Effect of Vicia sativa L. on Motility, Mortality and Expression Levels of hsp Genes in J2 Stage of Meloidogyne hapla.Journal of nematology · 2023Article
- Live imaging of apoptotic signaling flow using tunable combinatorial FRET-based bioprobes for cell population analysis of caspase cascades.Scientific reports · 2022Article
- Coupling of growth rate and developmental tempo reduces body size heterogeneity in C. elegans.Nature communications · 2022Article
- Nematodes as Ghosts of Land Use Past: Elucidating the Roles of Soil Nematode Community Studies as Indicators of Soil Health and Land Management Practices.Applied biochemistry and biotechnology · 2022Review
- Introns control stochastic allele expression bias.Nature communications · 2021Article
- Gene-Environment Interactions and Stochastic Variations in the Gero-Exposome.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Article
- Career Retrospective: Tom Johnson-Genetics, Genomics, Stress, Stochastic Variation, and Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Cell-to-cell variation in gene expression and the aging process.GeroScience · 2021Review
- Inhibition of mTOR decreases insoluble proteins burden by reducing translation in C. elegans.Biogerontology · 2021Article
- Article
- Proteostasis is adaptive: Balancing chaperone holdases against foldases.PLoS computational biology · 2020Article
- Transcriptome Analysis of the NematodeFrontiers in physiology · 2020Article
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Authors and funding
8 authors.
Funding
Abstract
Many traits vary among isogenic individuals in homogeneous environments. In microbes, plants and animals, variation in the protein chaperone system affects many such traits. In the animal model C. elegans, the expression level of hsp-16.2 chaperone biomarkers correlates with or predicts the penetrance of mutations and lifespan after heat shock. But the physiological mechanisms causing cells to express different amounts of the biomarker were unknown. Here, we used an in vivo microscopy approach to dissect different contributions to cell-to-cell variation in hsp-16.2 expression in the intestines of young adult animals, which generate the most lifespan predicting signal. While we detected both cell autonomous intrinsic noise and signaling noise, we found both contributions were relatively unimportant. The major contributor to cell-to-cell variation in biomarker expression was general differences in protein dosage. The hsp-16.2 biomarker reveals states of high or low effective dosage for many genes.
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