Evidence map›Paper›PMID 31844016›Full record

ArticleAntimicrobial agents and chemotherapy2020

Transferable Multidrug-Resistance Plasmid Carrying a Novel Macrolide-Clindamycin Resistance Gene,

Sae Aoki, Keisuke Nakase, Hidemasa Nakaminami, Takeaki Wajima, Nobukazu Hayashi, Norihisa Noguchi

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07392047 (Comparison Of The Efficacy Of 2% Metronidazole Gel Versus 1% Clindamycin Gel In The Treatment Of Moderate Acne Vulgaris), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07392047 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Comparison Of The Efficacy Of 2% Metronidazole Gel Versus 1% Clindamycin Gel In The Treatment Of Moderate Acne Vulgaris

TypeinterventionalSponsorJinnah Postgraduate Medical CentreRan2026 to 2026Enrolled60ConditionsAcne VulgarisArmsMetronidazole Topical Gel 2%, Clindamycin Topical Gel 1%
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Antibiotic resistance rates inFrontiers in microbiology · 2025
    Pooled it
  2. Review
  3. Article
  4. Review
  5. Comparative genomic analyses ofFrontiers in microbiology · 2024
    Article
  6. Review
  7. Frontiers in immunology · 2024
    Article
  8. Article
  9. Topical Antibiotic Treatment in Dermatology.Antibiotics (Basel, Switzerland) · 2023
    Review
  10. Article
  11. Article
  12. Genomic Analysis ofMicroorganisms · 2021
    Article
  13. Potential Target Site for Inhibitors in MLSAntibiotics (Basel, Switzerland) · 2021
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sae AokiDepartment of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.
Keisuke NakaseDepartment of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan nakase@toyaku.ac.jp.ORCID 0000-0002-9205-3008
Hidemasa NakaminamiDepartment of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.ORCID 0000-0003-2889-8257
Takeaki WajimaDepartment of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.ORCID 0000-0001-9506-707X
Nobukazu HayashiDepartment of Dermatology, Toranomon Hospital, Tokyo, Japan.
Norihisa NoguchiDepartment of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.
Tokyo University of Pharmacy and Life Sciences · JPToranomon Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial-resistant

Indexed as

Genome, BacterialAcne VulgarisAnti-Bacterial AgentsBacterial ProteinsClindamycinConjugation, GeneticDrug Resistance, Multiple, BacterialGene ExpressionGene Transfer, HorizontalHumansMacrolidesMicrobial Sensitivity TestsPhylogenyPlasmidsPropionibacteriaceaeRNA, Ribosomal, 23SAnti-Bacterial AgentsBacterial ProteinsClindamycinMacrolidesRNA, Ribosomal, 23STetracyclinesCutibacterium acneserm(50)multidrug resistanceplasmidtet(W)

Identifiers

PMID31844016
PMCPMC7038278
OpenAlexW2996600731

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.