Evidence map›Paper›PMID 31844012›Full record

ArticleAntimicrobial agents and chemotherapy2020

Protective Efficacy of Monoclonal Antibodies Neutralizing Alpha-Hemolysin and Bicomponent Leukocidins in a Rabbit Model of Staphylococcus aureus Necrotizing Pneumonia.

Trang T T Vu, Nhu T Q Nguyen, Vuvi G Tran, Emmanuelle Gras, Yanjie Mao, David H Jung, Christine Tkaczyk, Bret R Sellman, Binh An Diep

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. The virulence toolkit of Staphylococcus aureus: a comprehensive review of toxin diversity, molecular mechanisms, and clinical implications.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Review
  3. Article
  4. Development and validation of a rabbit model ofFrontiers in cellular and infection microbiology · 2023
    Article
  5. Article
  6. Article
  7. Review
  8. Mucosa-Associated Invariant T Cell Hypersensitivity toJournal of immunology (Baltimore, Md. : 1950) · 2022
    Article
  9. Article
  10. Review
  11. Antioxidants & redox signaling · 2021
    Review
  12. Review
  13. Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Trang T T VuDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Nhu T Q NguyenDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Vuvi G TranDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Emmanuelle GrasDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Yanjie MaoDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
David H JungDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Christine TkaczykMicrobial Sciences, AstraZeneca, Gaithersburg, Maryland, USA.
Bret R SellmanMicrobial Sciences, AstraZeneca, Gaithersburg, Maryland, USA bret.sellman@astrazeneca.com binh.diep@ucsf.edu.
Binh An DiepDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA bret.sellman@astrazeneca.com binh.diep@ucsf.edu.
University of California, San Francisco · USAstraZeneca (United States) · USUniversité de Tours · FR

Funding

Mechanisms of PVL-induced Acute Lung InjuryR01AI087674 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DIEP, BINH AN · 2010 to 2014
$2.1M
NIAID NIH HHS R01 AI087674
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Acute Lung InjuryAnimalsAntibodies, MonoclonalDisease Models, AnimalHemolysin ProteinsInflammationLeukocidinsMethicillin-Resistant Staphylococcus aureusPneumonia, NecrotizingRabbitsStaphylococcus aureusAntibodies, MonoclonalHemolysin ProteinsLeukocidinsacute lung inflammationnecrotizing pneumoniaStaphylococcus aureustherapeutic antibodies

Identifiers

PMID31844012
PMCPMC7038280
OpenAlexW2995881394

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.