Evidence map›Paper›PMID 31844010›Full record

ArticleAntimicrobial agents and chemotherapy2020

Association of Lipid Levels with Mefloquine and Carboxy-Mefloquine Concentrations in Patients with Uncomplicated Falciparum Malaria.

José Luiz Fernandes Vieira, Juan Gonzalo Bardalez Rivera, Luann Wendel Pereira de Sena, Michelle Valeria Dias Ferreira

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 76% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

José Luiz Fernandes VieiraPara Federal University, Pharmacy Faculty, Campus Universitario do Guama, Belem, Para, Brazil jvieira@ufpa.br.
Juan Gonzalo Bardalez RiveraPara Federal University, Pharmacy Faculty, Campus Universitario do Guama, Belem, Para, Brazil.
Luann Wendel Pereira de SenaPara Federal University, Pharmacy Faculty, Campus Universitario do Guama, Belem, Para, Brazil.
Michelle Valeria Dias FerreiraPara Federal University, Pharmacy Faculty, Campus Universitario do Guama, Belem, Para, Brazil.
Universidade Federal do Pará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mefloquine shows a high capacity to bind plasma proteins, which influences the amount of drug in erythrocytes. The study investigated the association of lipids levels with plasma concentrations of mefloquine and carboxy-mefloquine in 85 Brazilian patients with uncomplicated falciparum malaria. There were no significant associations between the total cholesterol or triglycerides with plasma concentrations of mefloquine and of carboxy-mefloquine. Lipoprotein levels explained 25.68% and 18.31% of mefloquine and carboxy-mefloquine plasma concentrations, respectively.

Indexed as

AdultAntimalarialsArtesunateBiotransformationBrazilCholesterol, HDLCholesterol, LDLCholesterol, VLDLDrug Therapy, CombinationErythrocytesHumansMalaria, FalciparumMaleMefloquinePlasmodium falciparumSeverity of Illness IndexAntimalarialsArtesunateCholesterol, HDLCholesterol, LDLCholesterol, VLDLMefloquineRo 21-5104Triglyceridesinfectious diseaseslipidslipoproteinsmalariamefloquine

Identifiers

PMID31844010
PMCPMC7038304
OpenAlexW2995905699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.