Evidence map›Paper›PMID 31844004›Full record

ArticleAntimicrobial agents and chemotherapy2020

Ability of Bicarbonate Supplementation To Sensitize Selected Methicillin-Resistant

Warren E Rose, Ana M Bienvenida, Yan Q Xiong, Henry F Chambers, Arnold S Bayer, Selvi C Ersoy

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 23 citations in OpenAlex.

  1. Genomic investigation and clinical correlates of theAntimicrobial agents and chemotherapy · 2024
    Trial
  2. An Achilles' heel for methicillin-resistantAntimicrobial agents and chemotherapy · 2026
    Review
  3. Article
  4. Review
  5. Defects in anaplerotic metabolism sensitizeMicrobiology spectrum · 2025
    Article
  6. Article
  7. Phenotypic and genotypic correlates of the sodium bicarbonate-responsive phenotype among methicillin-resistant Staphylococcus aureus isolates from skin and soft-tissue infections.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2025
    Article
  8. Article
  9. Review
  10. Sensitizing methicillin-resistantAntimicrobial agents and chemotherapy · 2024
    Article
  11. Measuring beta-lactam minimum inhibitory concentrations inJournal of clinical microbiology · 2024
    Review
  12. Article
  13. Role of the NaHCOMicrobiology spectrum · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Impacts of NaHCOAntibiotics (Basel, Switzerland) · 2022
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Warren E RoseSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin, USA warren.rose@wisc.edu.
Ana M BienvenidaDepartment of Pharmacy, UW Health, Madison, Wisconsin, USA.
Yan Q XiongThe Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Henry F ChambersUniversity of California at San Francisco School of Medicine, San Francisco, California, USA.
Arnold S Bayer *The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Selvi C Ersoy *The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
UCLA Medical Center · USHarbor–UCLA Medical Center · USUniversity of California, San Francisco · USUniversity of Wisconsin Health · USUniversity of Wisconsin–Madison · US

Funding

Mechanisms and use of penicillin-binding protein inhibition to optimize cationic peptide anti-MRSA treatmentR01AI132627 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI ROSE, WARREN E · 2017 to 2021
$2.1M
Bicarbonate-Mediated Enhancement of Beta-Lactam-MRSA Killing: Mechanisms and Clinical TranslatabilityR01AI146078 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI XIONG, YAN Q. · 2019 to 2023
$1.9M
NIAID NIH HHS R01 AI132627NIAID NIH HHS R01 AI146078
6 · The paper itself

Abstract

Supplementation of standard growth media (cation-adjusted Mueller-Hinton Broth [CAMHB]) with bicarbonate (NaHCO

Indexed as

AnimalsAnti-Bacterial Agentsbeta-LactamsBicarbonatesCefazolinMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsOxacillinRabbitsAnti-Bacterial Agentsbeta-LactamsBicarbonatesCefazolinOxacillinbeta-lactamsbicarbonatemethicillin resistanceMRSAStaphylococcus aureus

Identifiers

PMID31844004
PMCPMC7038310
OpenAlexW2994777261

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.