Evidence map›Paper›PMID 31843998›Full record

ArticleAntimicrobial agents and chemotherapy2020

Whole-Genome Approach to Understanding the Mechanism of Action of a Histatin 5-Derived Peptide.

Cody B Bullock, David S McNabb, Inés Pinto

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Salivary Histatin 5 Level in Women with Vaginal Candidiasis.International journal of clinical practice · 2022
    Article
  2. Review
  3. In Vitro and In Vivo Anti-Journal of fungi (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Cody B BullockDepartment of Biological Sciences, University of Arkansas, Fayetteville, Arkansas, USA.
David S McNabbDepartment of Biological Sciences, University of Arkansas, Fayetteville, Arkansas, USA.
Inés PintoDepartment of Biological Sciences, University of Arkansas, Fayetteville, Arkansas, USA ipinto@uark.edu.
University of Arkansas at Fayetteville · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of opportunistic fungal infections that threaten immunocompromised patients, along with the limited arsenal of antifungal drugs, calls for renewed efforts to develop novel antifungal therapies. Antimicrobial peptides have garnered interest as potential therapeutics. Among naturally occurring peptides, histatin 5 is a well-characterized 24-amino-acid peptide with strong antifungal activity. Our lab has identified a smaller histatin derivative, KM29, with stronger activity against multiple

Indexed as

Antifungal AgentsCandidaCandida albicansHistatinsMembrane Potential, MitochondrialMicrobial Sensitivity TestsPeptidesReactive Oxygen SpeciesSaccharomyces cerevisiaeAntifungal AgentsHistatinsPeptidesReactive Oxygen Speciesantimicrobial peptideCandidafungal pathogenesis

Identifiers

PMID31843998
PMCPMC7038261
OpenAlexW2995770120

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.