Evidence map›Paper›PMID 31843965›Full record

ArticleInfection and immunity2020

Interleukin-4 Signaling Plays a Major Role in Urogenital Schistosomiasis-Associated Bladder Pathogenesis.

Evaristus C Mbanefo, Chi-Ling Fu, Christina P Ho, Loc Le, Kenji Ishida, Olfat Hammam, Michael H Hsieh

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
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  7. The past, present, and future of immunotherapy for bladder tumors.Medical oncology (Northwood, London, England) · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Evaristus C MbanefoDivision of Urology, Children's National Medical Center, Washington, DC, USA.
Chi-Ling FuStanford University School of Medicine, Stanford, California, USA.
Christina P HoDivision of Urology, Children's National Medical Center, Washington, DC, USA.
Loc LeBladder Immunology Group, Biomedical Research Institute, Rockville, Maryland, USA.
Kenji IshidaBladder Immunology Group, Biomedical Research Institute, Rockville, Maryland, USA.
Olfat HammamTheodor Bilharz Research Institute, Giza, Egypt.
Michael H HsiehDivision of Urology, Children's National Medical Center, Washington, DC, USA mhsieh@cnmc.org.
Biomedical Research Institute · USChildren's National · USStanford University · USTexas Tech University · USTheodor Bilharz Research Institute · EG

Funding

Therapeutic Exploitation of IPSE, a Urogenital Parasite-Derived Host Modulatory Protein, for Bladder Hypersensitivity SyndromesR01DK113504 · NIDDK · CHILDREN'S RESEARCH INSTITUTE · PI HSIEH, MICHAEL HARRISON · 2017 to 2021
$2.4M
Defining the Immunomodulatory Niche of Schistosoma haematobium IPSER56AI119168 · NIAID · BIOMEDICAL RESEARCH INSTITUTE · PI HSIEH, MICHAEL HARRISON · 2015 to 2015
$471k
NIAID NIH HHS R56 AI119168NIDDK NIH HHS R01 DK113504
6 · The paper itself

Abstract

Interleukin-4 (IL-4) is crucial in many helminth infections, but its role in urogenital schistosomiasis, infection with

Indexed as

Schistosomiasis haematobiaAnimalsDisease Models, AnimalInterleukin-4MiceSchistosoma haematobiumSignal TransductionUrinary BladderInterleukin-4bladderIL-4Schistosomaschistosomiasistype-2 immunityurogenital

Identifiers

PMID31843965
PMCPMC7035943
OpenAlexW2996921182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.