Evidence map›Paper›PMID 31843938›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

In situ self-assembling Au-DNA complexes for targeted cancer bioimaging and inhibition.

Maonan Wang, Yun Chen, Weijuan Cai, Huan Feng, Tianyu Du, Weiwei Liu, Hui Jiang, Alberto Pasquarelli, Yossi Weizmann, Xuemei Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
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  6. Targeting ferroptosis in melanoma: cancer therapeutics.Cell communication and signaling : CCS · 2023
    Review
  7. Article
  8. Review
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  13. Review
  14. Article
  15. Article
  16. Aging · 2020
    Article
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  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maonan WangState Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), School of Biological Science and Medical Engineering, Southeast University, 210096 Nanjing, China.
Yun ChenState Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), School of Biological Science and Medical Engineering, Southeast University, 210096 Nanjing, China.
Weijuan CaiState Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), School of Biological Science and Medical Engineering, Southeast University, 210096 Nanjing, China.
Huan FengState Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), School of Biological Science and Medical Engineering, Southeast University, 210096 Nanjing, China.
Tianyu DuState Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), School of Biological Science and Medical Engineering, Southeast University, 210096 Nanjing, China.
Weiwei LiuState Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), School of Biological Science and Medical Engineering, Southeast University, 210096 Nanjing, China.
Hui JiangState Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), School of Biological Science and Medical Engineering, Southeast University, 210096 Nanjing, China.
Alberto PasquarelliInstitute of Electron Devices and Circuits, Ulm University, 89069 Ulm, Germany.
Yossi WeizmannDepartment of Chemistry, Ben-Gurion University of the Negev, 8410501 Beer-Sheva, Israel yweizmann@bgu.ac.il xuewang@seu.edu.cn.
Xuemei WangState Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), School of Biological Science and Medical Engineering, Southeast University, 210096 Nanjing, China; yweizmann@bgu.ac.il xuewang@seu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer remains one of the most challenging diseases to treat. For accurate cancer diagnosis and targeted therapy, it is important to assess the localization of the affected area of cancers. The general approaches for cancer diagnostics include pathological assessments and imaging. However, these methods only generally assess the tumor area. In this study, by taking advantage of the unique microenvironment of cancers, we effectively utilize in situ self-assembled biosynthetic fluorescent gold nanocluster-DNA (GNC-DNA) complexes to facilitate safe and targeted cancer theranostics. In in vitro and in vivo tumor models, our self-assembling biosynthetic approach allowed for precise bioimaging and inhibited cancer growth after one injection of DNA and gold precursors. These results demonstrate that in situ bioresponsive self-assembling GNC-PTEN (phosphatase and tensin homolog) complexes could be an effective noninvasive technique for accurate cancer bioimaging and treatment, thus providing a safe and promising cancer theranostics platform for cancer therapy.

Indexed as

A549 CellsAnimalsCell Line, TumorDisease Models, AnimalDNAGoldHeLa CellsHumansMetal NanoparticlesMiceNeoplasmsPTEN PhosphohydrolaseTheranostic NanomedicineTumor MicroenvironmentDNAGoldPTEN PhosphohydrolasePten protein, mousebiosynthetic complexescancer bioimaging and inhibitionself-assembling GNC-DNA complexes

Identifiers

PMID31843938
PMCPMC6955332

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.