ArticleProceedings of the National Academy of Sciences of the United States of America2020
How tissue fluidity influences brain tumor progression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.
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Who cites it
85 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Changes in Tissue Fluidity Predict Tumor Aggressiveness In Vivo.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Pooled it
- Transient Cytoskeletal Anisotropy Encodes Short-Term Mechanical Memory in Glioblastoma Cells.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Contact percolation governs collective motility via mechano-chemical feedback in heterogeneous breast cancer.Nature communications · 2026Article
- Review
- Matrix stress relaxation drives glioblastoma cell response in viscoelastic biomaterials.Science advances · 2026Article
- Multifrequency magnetic resonance elastography for predicting pancreatic cancer aggressiveness and patient survival.European radiology · 2026Article
- Nanomedicine targeting ECM stiffness: restoring mechanical homeostasis for cancer immunotherapy.Materials today. Bio · 2026Review
- Impact of static and dynamic magneto-mechanical stimulation with vortex microdiscs on glioblastoma cells cultured on 2D substrates with physiological stiffness.Nanoscale advances · 2026Article
- Mechanical instability as a signature of viscoelastic decoupling at the tumor-brain interface.Biomaterials advances · 2026Article
- MR elastography in patients with hepatocellular carcinoma: tumor stiffening during compression induced by respiration to assess microvascular invasion.European radiology · 2026Article
- Elasticity-guided tumor resection: applying biomechanical information to neurosurgical practice.Acta neurochirurgica · 2026Review
- Feasibility of multifrequency MR elastography of the seminal vesicles in healthy men, benign prostatic hyperplasia, and prostate cancer.European radiology experimental · 2026Article
- Open micro-valley chip reveals long-term viscosity-induced glioblastoma cellular invasion states.Microsystems & nanoengineering · 2026Article
- Wide-field and non-invasive imaging of brain tumours with scattered light techniques.Biomedical optics express · 2026Article
- Comparative cross-methodological analysis of the IDH-wildtype glioblastoma tumor microenvironment.Journal of cancer research and clinical oncology · 2026Article
- Scaling the glassy dynamics of active particles: Tunable fragility and reentrance.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Engineering 3D neural models of neurodegeneration: the Neural Microenvironment Design Code (NMDC), design principles, and emerging new approach methodologies.NAM journal · 2026Review
- Stiffness and Tissue Viscosity in a Cerebral Neoplasm Measured by Preoperative Multifrequency Magnetic Resonance Elastography (MRE) Guide the Differential Diagnosis of Brain Tumors by Ruling Out Glioma.Case reports in medicine · 2026Article
- Cancer cells metastasize in several types of cancer via two distinct routes, probably based on mechanical signals.Frontiers in cell and developmental biology · 2026Review
- Crosstalk in the brain tumor microenvironment: mechanisms, therapeutic strategies, and clinical advances.Military Medical Research · 2026Review
25 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanical properties of biological tissues and, above all, their solid or fluid behavior influence the spread of malignant tumors. While it is known that solid tumors tend to have higher mechanical rigidity, allowing them to aggressively invade and spread in solid surrounding healthy tissue, it is unknown how softer tumors can grow within a more rigid environment such as the brain. Here, we use in vivo magnetic resonance elastography (MRE) to elucidate the role of anomalous fluidity for the invasive growth of soft brain tumors, showing that aggressive glioblastomas (GBMs) have higher water content while behaving like solids. Conversely, our data show that benign meningiomas (MENs), which contain less water than brain tissue, are characterized by fluid-like behavior. The fact that the 2 tumor entities do not differ in their soft properties suggests that fluidity plays an important role for a tumor's aggressiveness and infiltrative potential. Using tissue-mimicking phantoms, we show that the anomalous fluidity of neurotumors physically enables GBMs to penetrate surrounding tissue, a phenomenon similar to Saffman-Taylor viscous-fingering instabilities, which occur at moving interfaces between fluids of different viscosity. Thus, targeting tissue fluidity of malignant tumors might open horizons for the diagnosis and treatment of cancer.
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