Evidence map›Paper›PMID 31843262›Full record

ArticleBiophysical journal2020

Stairway to Asymmetry: Five Steps to Lipid-Asymmetric Proteoliposomes.

Marie Markones, Anika Fippel, Michael Kaiser, Carina Drechsler, Carola Hunte, Heiko Heerklotz

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Marie MarkonesInstitute for Pharmaceutical Sciences, University of Freiburg, Breisgau, Germany; Signaling Research Centers BIOSS and CIBSS, University of Freiburg, Breisgau, Germany; HSGS Hermann Staudinger Graduate School, University of Freiburg, Breisgau, Germany. Electronic address: marie.markones@pharmazie.uni-freiburg.de.
Anika FippelInstitute for Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, Breisgau, Germany; HSGS Hermann Staudinger Graduate School, University of Freiburg, Breisgau, Germany.
Michael KaiserInstitute for Pharmaceutical Sciences, University of Freiburg, Breisgau, Germany; HSGS Hermann Staudinger Graduate School, University of Freiburg, Breisgau, Germany.
Carina DrechslerInstitute for Pharmaceutical Sciences, University of Freiburg, Breisgau, Germany; Signaling Research Centers BIOSS and CIBSS, University of Freiburg, Breisgau, Germany.
Carola HunteSignaling Research Centers BIOSS and CIBSS, University of Freiburg, Breisgau, Germany; Institute for Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, Breisgau, Germany.
Heiko HeerklotzInstitute for Pharmaceutical Sciences, University of Freiburg, Breisgau, Germany; Signaling Research Centers BIOSS and CIBSS, University of Freiburg, Breisgau, Germany; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
University of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Membrane proteins are embedded in a complex lipid environment that influences their structure and function. One key feature of nearly all biological membranes is a distinct lipid asymmetry. However, the influence of membrane asymmetry on proteins is poorly understood, and novel asymmetric proteoliposome systems are beneficial. To our knowledge, we present the first study on a multispanning protein incorporated in large unilamellar liposomes showing a stable lipid asymmetry. These asymmetric proteoliposomes contain the Na

Indexed as

LipidsProteolipidsSalmonella typhimuriumUnilamellar LiposomesLipidsProteolipidsproteoliposomesUnilamellar Liposomes

Identifiers

PMID31843262
PMCPMC6976795
OpenAlexW2991641956

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.