ArticleOrphanet journal of rare diseases2019
Histopathological features of condylar hyperplasia and condylar Osteochondroma: a comparison study.
Article in Orphanet journal of rare diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Decision-Making in Unilateral Progressive Condylar Growth of the Mandible: Biological Insights and the Role of Proportional Condylectomy.Journal of clinical medicine · 2026Review
- Expert consensus on treatment of condylar hyperplasia and secondary dento-maxillofacial deformities.International journal of oral science · 2026Article
- Condylar Osteochondroma in an Older Adult With Facial Asymmetry: Case Report and Differentiation From Condylar Hyperplasia.Case reports in dentistry · 2026Article
- Concurrent resection and orthognathic surgery for the management of mandibular condyle osteoma: a case report and literature review.Frontiers in oral health · 2026Article
- Low condylectomy and functional therapy alone for unilateral condylar osteochondroma treatment: case report and literature review.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2024Review
- Evaluating Surgical Approaches for Hemimandibular Hyperplasia Associated with Osteochondroma: A Systematic Literature Review.Journal of clinical medicine · 2024Review
- Osteochondroma of the Mandibular Condyle: A Rare Case Presentation With Literature Review.Cureus · 2023Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBoth mandibular condylar hyperplasia and condylar osteochondroma can lead to maxillofacial skeletal asymmetry and malocclusion, although they exhibit different biological behavior. This study attempted to compare the histological features of mandibular condylar hyperplasia and condylar osteochondroma using hematoxylin-and-eosin (H&E) staining, and immunohistochemistry staining of PCNA and EXT1 with quantitative analysis method.
resultsThe H&E staining showed that condylar hyperplasia and condylar osteochondroma could be divided into four histological types and exhibited features of different endochondral ossification stages. There was evidence of a thicker cartilage cap in condylar osteochondroma as compared condylar hyperplasia (P = 0.018). The percentage of bone formation in condylar osteochondroma was larger than was found in condylar hyperplasia (P = 0.04). Immunohistochemical staining showed that PCNA was mainly located in the undifferentiated mesenchymal layer and the hypertrophic cartilage layer, and there were more PCNA positive cells in the condylar osteochondroma (P = 0.007). EXT1 was mainly expressed in the cartilage layer, and there was also a higher positive rate of EXT1 in condylar osteochondroma (P = 0.0366). The thicker cartilage cap, higher bone formation rate and higher PCNA positive rate indicated a higher rate of proliferative activity in condylar osteochondroma. The more significant positive rate of EXT1 in condylar osteochondroma implied differential biological characteristic as compared to condylar hyperplasia.
conclusionsThese features might be useful in histopathologically distinguishing condylar hyperplasia and osteochondroma.
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