Evidence map›Paper›PMID 31842959›Full record

ArticleTrials2019

Decreasing postoperative cognitive deficits after heart surgery: protocol for a randomized controlled trial on cognitive training.

Marius Butz, Jasmin El Shazly, Gebhard Sammer, Marlene Tschernatsch, Sabrina Kastaun, Mesut Yenigün, Tobias Braun, Manfred Kaps, Andreas Böning, Ulrike Puvogel and 5 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Marius ButzDepartment of Neurology, Heart and Brain Research Group, University Hospital Giessen and Marburg, Klinikstraße 33, 35385, Giessen, Germany. marius.butz@neuro.med.uni-giessen.de.ORCID http://orcid.org/0000-0002-9088-5695
Jasmin El ShazlyDepartment of Neurology, Heart and Brain Research Group, University Hospital Giessen and Marburg, Klinikstraße 33, 35385, Giessen, Germany.
Gebhard SammerCognitive Neuroscience at the Centre of Psychiatry, University Giessen, Klinikstraße 36, 35385, Giessen, Germany.
Marlene TschernatschDepartment of Neurology, Community Hospital Friedberg, Ockstädter Straße 3-5, 61169, Friedberg, Germany.
Sabrina KastaunInstitute of General Practice, Addiction Research and Clinical Epidemiology Unit, Medical Faculty of the Heinrich-Heine University Düsseldorf, Werdener Straße 4, 40227, Düsseldorf, Germany.
Mesut YenigünDepartment of Neurology, Heart and Brain Research Group, University Hospital Giessen and Marburg, Klinikstraße 33, 35385, Giessen, Germany.
Tobias BraunDepartment of Neurology, Heart and Brain Research Group, University Hospital Giessen and Marburg, Klinikstraße 33, 35385, Giessen, Germany.
Manfred KapsDepartment of Neurology, Heart and Brain Research Group, University Hospital Giessen and Marburg, Klinikstraße 33, 35385, Giessen, Germany.
Andreas BöningDepartment of Cardiovascular Surgery, University Hospital Giessen and Marburg, Rudolf-Buchheim-Straße 7, 35385, Giessen, Germany.
Ulrike PuvogelDepartment of Cardiovascular Surgery, University Hospital Giessen and Marburg, Rudolf-Buchheim-Straße 7, 35385, Giessen, Germany.
Georg BachmannDepartment of Radiology, Kerckhoff Heart and Thorax Center, Benekestraße 2-8, 61231, Bad Nauheim, Germany.
Thomas MengdenDepartment of Rehabilitation, Kerckhoff Heart and Thorax Center, Ludwigstraße 41, 61231, Bad Nauheim, Germany.
Markus SchönburgDepartment of Cardiac Surgery, Kerckhoff Heart and Thorax Center, Benekestraße 2-8, 61231, Bad Nauheim, Germany.
Tibo GerrietsDepartment of Cardiac Surgery, Kerckhoff Heart and Thorax Center, Benekestraße 2-8, 61231, Bad Nauheim, Germany.
Martin JuenemannDepartment of Neurology, Heart and Brain Research Group, University Hospital Giessen and Marburg, Klinikstraße 33, 35385, Giessen, Germany.

Funding

Deutsche Stiftung für Herzforschung F/20/17Stiftung William G. Kerckhoff no information
6 · The paper itself

Abstract

backgroundThe occurrence of postoperative cognitive deficits, especially after heart surgery, has been demonstrated in several studies. These deficits can clearly be noticed by the patients and by their close relatives in daily life. Furthermore, postoperative cognitive deficits can decrease quality of life in social functioning and earning capacity. The aim of this study is to investigate whether early postoperative cognitive training can reduce subjective and objective postoperative cognitive deficits.

methodsThe proposed study is a multicenter, two-arm, randomized controlled trial involving 144 elderly patients undergoing elective heart-valve surgery with extracorporeal circulation. Patients will be assigned to either a training group or a control group. The intervention involves paper-and-pencil-based cognitive training, which is conducted for 36 min over a period of 18 days. The training starts about 1 week after surgery and is carried out during the hospitalized rehabilitation phase. The control group will not receive cognitive training or a placebo intervention. A detailed assessment of psychological functions and health-related quality of life prior to surgery at discharge from rehabilitation and 3 and 12 months after discharge will be performed. The primary outcome of this trial is the training effect on objective cognitive functions at discharge from rehabilitation. Secondary outcomes are the training effect on objective and subjective cognitive functions (3 and 12 months after discharge), depression, health-related quality of life, and the impact of perioperative cerebral ischemia on the training effect. Perioperative cerebral ischemia will be measured with postoperative magnetic resonance imaging including diffusion-weighted sequences. DISCUSSION: Should it be shown that our cognitive training can improve postoperative cognitive deficits and quality of life, one possibility could be to integrate this intervention into early rehabilitation. Furthermore, we hope that the investigation of perioperative ischemia by diffusion-weighted magnetic resonance imaging will improve our understanding of neurobiological factors influencing the course of postoperative cognitive plasticity.

trial registrationGerman Clinical Trials Register (DRKS), DRKS00015512. Retrospectively registered on 21 September 2018.

Indexed as

CognitionCognitive Behavioral TherapyCardiac Surgical ProceduresExtracorporeal CirculationGermanyHeart ValvesHumansMulticenter Studies as TopicPostoperative Cognitive ComplicationsProspective StudiesQuality of LifeRandomized Controlled Trials as TopicTime FactorsTreatment OutcomeCognitive trainingHeart surgeryMagnetic resonance imagingPostoperative cerebral microinfarctsPostoperative cognitive deficits

Identifiers

PMID31842959
PMCPMC6916013

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.