Evidence map›Paper›PMID 31842894›Full record

ArticleMalaria journal2019

Antibody responses within two leading Plasmodium vivax vaccine candidate antigens in three geographically diverse malaria-endemic regions of India.

Sonal Kale, Chander P Yadav, Pavitra N Rao, Sneh Shalini, Alex Eapen, Harish C Srivasatava, Surya K Sharma, Veena Pande, Jane M Carlton, Om P Singh and 1 more

Open access · goldAbstract read
In one paragraph

Article in Malaria journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Inter-Population Genetic Diversity and Clustering ofTropical medicine and infectious disease · 2023
    Article
  3. Naturally acquired antibody response toFrontiers in cellular and infection microbiology · 2023
    Article
  4. IgM antibody responses againstFrontiers in cellular and infection microbiology · 2023
    Article
  5. Article
  6. Frontiers in immunology · 2022
    Review
  7. Article
  8. Article
  9. Progress towards the development of aExpert review of vaccines · 2021
    Review
  10. Article
  11. Antibodies Against theFrontiers in cellular and infection microbiology · 2021
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Sonal KaleICMR-National Institute of Malaria Research, Sector 8, Dwarka, New Delhi, India.
Chander P YadavICMR-National Institute of Malaria Research, Sector 8, Dwarka, New Delhi, India.
Pavitra N RaoDepartment of Biology, Center for Genomics and Systems Biology, New York University, New York, USA.
Sneh ShaliniICMR-National Institute of Malaria Research, Sector 8, Dwarka, New Delhi, India.
Alex EapenNational Institute of Malaria Research Field Unit, Indian Council of Medical Research, National Institute of Epidemiology Campus, Ayapakkam, Chennai, Tamil Nadu, India.
Harish C SrivasatavaNational Institute of Malaria Research Field Unit, Civil Hospital, Nadiad, Gujarat, India.
Surya K SharmaJigyansha, International Center of Excellence for Malaria Research, Sector 1, Rourkela, Odisha, India.
Veena PandeDepartment of Biotechnology, Kumaun University, Nainital, Uttarakhand, India.
Jane M CarltonDepartment of Biology, Center for Genomics and Systems Biology, New York University, New York, USA.
Om P SinghICMR-National Institute of Malaria Research, Sector 8, Dwarka, New Delhi, India. singh@mrcindia.org.
Prashant K MallickICMR-National Institute of Malaria Research, Sector 8, Dwarka, New Delhi, India. pkmmrc@gmail.com.ORCID http://orcid.org/0000-0002-5866-717X
National Institute of Malaria Research · INKumaun University · INNew York University · USIndian Council of Medical Research · IN

Funding

Using Next-Generation Genomics to Study Antimalarial Drug Resistance in IndiaU19AI089676 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CARLTON, JANE M · 2010 to 2023
$22.6M
National Institute of Allergy and Infectious Diseases U19AI089676NIAID NIH HHS U19 AI089676
6 · The paper itself

Abstract

backgroundIdentifying highly immunogenic blood stage antigens which can work as target for naturally acquired antibodies in different eco-epidemiological settings is an important step for designing malaria vaccine. Blood stage proteins of Plasmodium vivax, apical membrane antigen-1 (PvAMA-1) and 19 kDa fragment of merozoite surface protein (PvMSP-1

methodsA total of 234 blood samples were collected from individuals living in three different eco-epidemiological settings, Chennai, Nadiad, and Rourkela of India. Indirect ELISA was performed to measure human IgG antibodies against recombinant PvAMA-1 and PvMSP-1

resultsThe overall seroprevalence was 40.6% for PvAMA-1 and 62.4% for PvMSP-1

conclusionThese data suggest that natural acquired antibody response is higher for PvMSP-1

Indexed as

AdolescentAdultAntibodies, ProtozoanAntibody FormationAntigens, ProtozoanChildEndemic DiseasesEnzyme-Linked Immunosorbent AssayFemaleGeographyHumansImmunoglobulin GIndiaMalaria, VivaxMaleMembrane ProteinsAntibodies, ProtozoanAntigens, Protozoanapical membrane antigen I, PlasmodiumImmunoglobulin GMembrane ProteinsMerozoite Surface Protein 1Protozoan ProteinsAntibody responseIndiaPlasmodium vivaxPvAMA-1PvMSP-119Seroprevalence

Identifiers

PMID31842894
PMCPMC6916228
OpenAlexW2996255550

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.