ArticleBMC veterinary research2019
Peste des petits ruminants pathogenesis on experimental infected goats by the Moroccan 2015 isolate.
Article in BMC veterinary research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Integrating Epidemiology, Immunology, and Host Genetics for Controlling Peste des Petits Ruminants in Goats.Viruses · 2026Review
- Age-Related Immune Responses and Long-Term Immunity in Adult Sheep and Goats Following Vaccination with the Nigeria 75/1 Live Attenuated PPR Vaccine.Veterinary sciences · 2026Article
- Comparative virulence study of locally circulating peste des petits ruminants virus (PPRV) strains in indigenous Ethiopian goats.BMC veterinary research · 2025Article
- Article
- Comparative study of HA and HNB staining RT-LAMP assays for peste des petits ruminants virus detection in West African Dwarf goats.Tropical animal health and production · 2023Article
- Article
- Simulating the Spread of Peste des Petits Ruminants in Kazakhstan Using the North American Animal Disease Spread Model.Transboundary and emerging diseases · 2023Article
- The Experimental Infection of Goats with Small Ruminant Morbillivirus Originated from Barbary Sheep.Pathogens (Basel, Switzerland) · 2022Article
- Comparative pathogenesis of peste des petits ruminants virus strains of difference virulence.Veterinary research · 2022Article
- Duration of Protective Immunity in Sheep Vaccinated with a Combined Vaccine against Peste des Petits Ruminants and Sheep Pox.Vaccines · 2021Article
- Transboundary Animal Diseases, an Overview of 17 Diseases with Potential for Global Spread and Serious Consequences.Animals : an open access journal from MDPI · 2021Review
- Assessment of the control measures of the category A diseases of Animal Health Law: peste des petits ruminants.EFSA journal. European Food Safety Authority · 2021Article
- Experimental infection of indigenous North African goats with goatpox virus.Acta veterinaria Scandinavica · 2021Article
- A Sequential Study on the Pathology of Peste Des Petits Ruminants and Tissue Distribution of the Virus Following Experimental Infection of Black Bengal Goats.Frontiers in veterinary science · 2021Article
- Field serological investigation for peste des petits ruminants, foot-and-mouth disease, and bluetongue diseases in illegally introduced animals in Egypt.Veterinary world · 2020Article
- Sentinel surveillance of selected veterinary and public health pathogens in camel population originating from Southern Punjab province, Pakistan.Acta tropica · 2020Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeste des petits ruminants (PPR) is a viral disease of major economic importance on small ruminants. Goats are usually known to be more susceptible to the disease. Infection chronology, virus circulation, and the disease early detection need to be better understood. This study evaluates the tissue tropism and pathogenesis of PPR following experimental infection of goats using a lineage IV virus, the most dominant in the world originated from Asia. PPRV infection was experimentally induced in 4 six-month-old goats by intra-nasal and intravenous route of cell virus suspension and from infectious mashed tissue. The clinical signs were observed and goats were euthanized at predetermined clinical score level for post-mortem examinations and PPRV detection by RT-PCR. Clinical signs of infection were present, pyrexia, serous-mucopurulent nasal discharges, coughing, diarrhea and asthenia, for both cell virus suspension and infectious mashed tissue. PPRV genome was highly detected in swabs and tissues with clinical signs dominated by pulmonary attack and digestive symptoms secondary.
resultsResults of this study indicates that PPRV is an invasive infection in animals that in a short period, less than 10 days, invade all vital organs. On live animals, early diagnostic may be easily done on lacrimal and rectal swabs.
conclusionThe experimental PPRV-infection model using the cell virus suspension is suitable for vaccine evaluation as a standard model.
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