ArticleBMC pulmonary medicine2019
Sex differences in the association between asthma incidence and modifiable risk factors in Korean middle-aged and older adults: NHIS-HEALS 10-year cohort.
Article in BMC pulmonary medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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12 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- The association between body mass index, abdominal fatness, and weight change and the risk of adult asthma: a systematic review and meta-analysis of cohort studies.Scientific reports · 2023Pooled it
- Socioeconomic, Behavioural, and Environmental Determinants of Asthma Inequalities in Europe: A Cross-Sectional Study Using EHIS Data.International journal of environmental research and public health · 2026Article
- Inverted L-shape association between a body shape index and peak expiratory flow among middle-aged and older adults: findings from the China Health and Retirement Longitudinal Study (CHARLS).Lipids in health and disease · 2025Article
- Association between the triglyceride glucose body mass index and asthma: evidence from NHANES 2011-2018.BMC pulmonary medicine · 2025Article
- Effectiveness of Asthma Home Management Manual and Low-Cost Air Filter on Quality of Life Among Asthma Adults: A 3-Arm Randomized Controlled Trial.Journal of multidisciplinary healthcare · 2024Article
- Association between waist circumference or weight change after smoking cessation and incidence of cardiovascular disease or all-cause death in Korean adults with type 2 diabetes.Frontiers in endocrinology · 2024Article
- Association between antibiotics and asthma risk among adults aged over 40 years: a nationally representative retrospective cohort study.BMJ open respiratory research · 2023Article
- Association of weight-adjusted-waist index with asthma prevalence and the age of first asthma onset in United States adults.Frontiers in endocrinology · 2023Article
- Obesity, Inflammation, and Severe Asthma: an Update.Current allergy and asthma reports · 2021Review
- Characteristics of older adult hospitalized patients with bronchial asthma: a retrospective study.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2021Article
- Different effects of smoking on atopic and non-atopic adult-onset asthma.Clinical and translational allergy · 2021Article
- Weight gain from early to middle adulthood increases the risk of incident asthma later in life in the United States: a retrospective cohort study.Respiratory research · 2021Article
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3 authors at 2 institutions in 1 country.
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Abstract
backgroundThis study investigated the sex-specific incidence of asthma and the effects of modifiable risk factors, particularly obesity, on asthma incidence among middle-aged and older individuals in Korea.
methodsWe used data from the National Health Insurance Service-Health Screening Cohort (NHIS-HEALS), which includes health examinees aged 40-79 years in 2002-2003. In total, 459,529 participants with baseline anthropometric measurements were followed-up for 10 years and the development of asthma was evaluated (2004-2013). For subgroup analysis, 246,019 participants who had body mass index (BMI) and waist circumference (WC) measurements taken in 2008-2009 were included in the analysis of the asthma incidence for 2010-2013. Factors associated with asthma were analysed using Cox proportional hazard models.
resultsThe cohort comprised 4,248,813 (men, 2,358,541; women, 1,890,272) person-years of follow-up for 2004-2013. The asthma incidence was 10.58 and 15.03 per 1000 person-years for men and women, respectively. Asthma incidence increased with age, notably so in men. Obesity based on the baseline BMI was significantly associated with asthma development in both sexes (men, HR = 1.23, 95% confidence interval (CI) = 1.13-1.34; women, HR = 1.40 95% CI = 1.32-1.48). High WC was also related to asthma incidence in both sexes with statistical significance (men, HR = 1.34, 95% CI = 1.16-1.57; women, HR = 1.19 95% CI = 1.03-1.37). Analysis of the combined effects of BMI and WC showed that men had a higher asthma risk in the group with both general obesity and abdominal obesity than in the group with non-abdominal obesity and normal BMI. However, obese women had a higher risk of asthma regardless of abdominal obesity. Similarly, smoking was associated with asthma in both sexes but drinking and physical activity showed different associations between the sexes.
conclusionsOur results revealed that asthma incidence was substantially high at old age and lifestyle factors were associated with asthma development. Practical strategies including weight control and healthy lifestyle modification are required to prevent asthma in older people.
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