ArticleBMC psychiatry2019
Sexual dimorphism in up-regulation of suppressors of cytokine signaling genes in patients with bipolar disorder.
Article in BMC psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Children and adolescents with psychiatric disorders have high relative leptin levels upon adjustment for sex, BMI, and pubertal status.European child & adolescent psychiatry · 2026Article
- DNA methylation in bipolar disorder: mechanistic insights and translational challenges.Frontiers in pharmacology · 2026Review
- Sex-differential cognitive performance on MCCB of youth with BD-II depression.BMC psychiatry · 2024Article
- Sex Differences in Brain Disorders.International journal of molecular sciences · 2023Review
- Assessment of Expression ofFrontiers in immunology · 2021Article
- SIGIRR and TNFAIP3 Are Differentially Expressed in Both PBMC and TNF-α Secreting Cells of Patients With Major Depressive Disorder.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProteins encoded by Suppressors of cytokine signaling (SOCS) genes have critical roles in the regulation of immune responses. Meanwhile, several lines of evidence support the presence of immune dysfunction in bipolar disorder (BD) patients.
methodsIn the present study, we assessed expression levels of SOCS1-3 and SOCS5 genes in peripheral blood of patients with BD and healthy subjects.
resultsAll SOCS genes were up-regulated in patients compared with healthy subjects. However, when comparing patients with sex-matched controls, the significant differences were observed only in the male subjects except for SOCS5 which was up-regulated in both male and female patients compared with the corresponding control subjects. Significant pairwise correlations were found between expression levels of genes in both patients and controls. Based on the area under curve values, SOCS5 had the best performance in the differentiation of disease status in study participants (AUC = 0.92). Combination of four genes increased the specificity of tests and resulted in diagnostic power of 0.93.
conclusionTaken together, these data suggest a role for SOCS genes in the pathogenesis of BD especially in the male subjects. Moreover, peripheral expression levels of SOCS genes might be used as a subsection of a panel of diagnostic biomarkers in BD.
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