Evidence map›Paper›PMID 31842394›Full record

Trial reportNutrients2019

The Effect of Antioxidant Supplementation in Patients with Tinnitus and Normal Hearing or Hearing Loss: A Randomized, Double-Blind, Placebo Controlled Trial.

Anna I Petridou, Eleftheria T Zagora, Petros Petridis, George S Korres, Maria Gazouli, Ioannis Xenelis, Efthymios Kyrodimos, Georgia Kontothanasi, Andriana C Kaliora

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05646693 phase2unknown statusnot on this mapstarted 2022, after this paper: background citation

Effect of Combined Antioxidant Therapy on Oxidative Stress Markers and Inflammatory in Patients With Chronic Subjective Endotic Tinnitus

TypeinterventionalSponsorUniversity of GuadalajaraRan2022 to 2024Enrolled58ConditionsTinnitus, Subjective, Tinnitus, Bilateral, Antioxidant Therapy, Psychiatric DrugsArmsDrusen Mega®, Sertraline, Placebo
NCT06718452 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Treatment of Tinnitus Targeting Neuroinflammation. umPEALUT as Possible Option

TypeinterventionalSponsorUniversity of Campania Luigi VanvitelliRan2026 to 2026Enrolled100ConditionsTinnitus, NeuroinflammationArmsPEA-LUT 2 sachet day, Placebo, umPEALUT + Rutin + 5 hTp
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Effectiveness of lifestyle-modification approach (a randomized-controlled program of diet restriction and treadmill walking exercise) on elderly's metabolic syndrome-associated subjective tinnitus.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Trial
  3. Trial
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  5. Review
  6. Article
  7. Article
  8. AUDISTIMAudiology research · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Objective and Measurable Biomarkers in Chronic Subjective Tinnitus.International journal of molecular sciences · 2021
    Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anna I Petridou1st ENT Department, School of Medicine, National and Kapodistrian University of Athens, Hippokration Hospital, 11527 Athens, Greece.
Eleftheria T ZagoraENT Department, General Hospital of Nikaia "Agios Panteleimon", Nikaia, 18454 Athens, Greece.
Petros PetridisENT Department, St. Johannes Hospital, 44137 Dortmund, Germany.
George S Korres2nd ENT Department, School of Medicine, National and Kapodistrian University of Athens, Attikon Hospital, 12462 Chaidari, Greece.ORCID 0000-0002-4527-9426
Maria GazouliDepartment of Biology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0002-3295-6811
Ioannis Xenelis1st ENT Department, School of Medicine, National and Kapodistrian University of Athens, Hippokration Hospital, 11527 Athens, Greece.
Efthymios Kyrodimos1st ENT Department, School of Medicine, National and Kapodistrian University of Athens, Hippokration Hospital, 11527 Athens, Greece.
Georgia KontothanasiENT Department, General Hospital of Nikaia "Agios Panteleimon", Nikaia, 18454 Athens, Greece.
Andriana C KalioraDepartment of Dietetics and Nutritional Science, School of Health Science and Education, Harokopio University, 17671 Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tinnitus is the perception of sound in the absence of any external stimulus. Oxidative stress is possibly involved in its pathogenesis and a variety of antioxidant compounds have been studied as potential treatment approaches. The objective of the present study was to assess the effects of antioxidant supplementation in tinnitus patients. This is a randomized, double-blind, placebo-controlled clinical trial. Patients (

Indexed as

Dietary SupplementsAdultAntioxidantsDouble-Blind MethodFemaleHearing LossHumansLipoproteins, LDLMaleMiddle AgedOxidation-ReductionSuperoxide DismutaseTinnitusTreatment OutcomeAntioxidantsLipoproteins, LDLSuperoxide Dismutasea-lipoic acidantioxidant supplementationmulti-vitamin supplementoxidative stresstinnitus

Identifiers

PMID31842394
PMCPMC6950042

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.