Evidence map›Paper›PMID 31842369›Full record

ArticleMarine drugs2019

A Versatile and Robust Serine Protease Inhibitor Scaffold from

Xingchen Chen, Darren Leahy, Jessica Van Haeften, Perry Hartfield, Peter J Prentis, Chloé A van der Burg, Joachim M Surm, Ana Pavasovic, Bruno Madio, Brett R Hamilton and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Xingchen ChenInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia.
Darren LeahyInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia.
Jessica Van HaeftenInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia.
Perry HartfieldSchool of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD 4000, Australia.
Peter J PrentisSchool of Earth, Environmental and Biological Sciences, Science and Engineering Faculty, Queensland University of Technology, Brisbane, QLD 4000, Australia.ORCID 0000-0001-6587-8875
Chloé A van der BurgInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia.
Joachim M SurmInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia.
Ana PavasovicInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia.
Bruno MadioInstitute for Molecular Bioscience, University of Queensland, St Lucia, QLD 4072, Australia.
Brett R HamiltonCentre for Advanced Imaging, University of Queensland, St Lucia, QLD 4072, Australia.
Glenn F KingInstitute for Molecular Bioscience, University of Queensland, St Lucia, QLD 4072, Australia.ORCID 0000-0002-2308-2200
Eivind A B UndheimCentre for Advanced Imaging, University of Queensland, St Lucia, QLD 4072, Australia.ORCID 0000-0002-8667-3999
Maria BrattsandDepartment of Medical Biosciences, Umeå University, 901 87 Umeå, Sweden.ORCID 0000-0001-7175-1336
Jonathan M HarrisInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia.
Queensland University of Technology · AUThe University of Queensland · AUUmeå University · SE

Funding

Australian Research Council 160101142, 140100832National Health and Medical Research Council 1059410, 1136889
6 · The paper itself

Abstract

Serine proteases play pivotal roles in normal physiology and a spectrum of patho-physiological processes. Accordingly, there is considerable interest in the discovery and design of potent serine protease inhibitors for therapeutic applications. This led to concerted efforts to discover versatile and robust molecular scaffolds for inhibitor design. This investigation is a bioprospecting study that aims to isolate and identify protease inhibitors from the cnidarian

Indexed as

AnimalsCattleChymotrypsinCnidariaComputer SimulationHumansMolecular Dynamics SimulationSerine ProteasesSerine Proteinase InhibitorsTrypsinTrypsin InhibitorsChymotrypsinSerine ProteasesSerine Proteinase InhibitorsTrypsinTrypsin InhibitorsActinia tenebrosakallikrein-related peptidasesKunitz inhibitormass spectrometry imagingmolecular dynamics simulationserine protease

Identifiers

PMID31842369
PMCPMC6950308
OpenAlexW2995812608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.