Evidence map›Paper›PMID 31842319›Full record

ArticleMarine drugs2019

Pharmaceutical Development and Safety Evaluation of a GMP-Grade Fucoidan for Molecular Diagnosis of Cardiovascular Diseases.

Cédric Chauvierre, Rachida Aid-Launais, Joël Aerts, Frédéric Chaubet, Murielle Maire, Lucas Chollet, Lydia Rolland, Roberta Bonafé, Silvia Rossi, Simona Bussi and 10 more

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. First-in-human study ofEJNMMI research · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Perspectives for the Use of Fucoidans in Clinical Oncology.International journal of molecular sciences · 2022
    Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 4 countries.

Cédric ChauvierreUniversité de Paris, UMRS1148, INSERM, F-75018 Paris, France.ORCID 0000-0002-0937-4709
Rachida Aid-LaunaisUniversité de Paris, UMRS1148, INSERM, F-75018 Paris, France.
Joël AertsX. Bichat Medical School, Université de Paris, UMS34 FRIM, F-75018 Paris, France.
Frédéric ChaubetUniversité de Paris, UMRS1148, INSERM, F-75018 Paris, France.ORCID 0000-0001-7375-0425
Murielle MaireUniversité de Paris, UMRS1148, INSERM, F-75018 Paris, France.
Lucas CholletUniversité de Paris, UMRS1148, INSERM, F-75018 Paris, France.
Lydia RollandAlgues & Mer, F-29242 Ouessant, France.
Roberta BonaféBracco Research Center, Bracco Imaging Spa, 20811 Colleretto Giacosa, Italy.
Silvia RossiBracco Research Center, Bracco Imaging Spa, 20811 Colleretto Giacosa, Italy.
Simona BussiBracco Research Center, Bracco Imaging Spa, 20811 Colleretto Giacosa, Italy.ORCID 0000-0002-6619-0404
Claudia CabellaBracco Research Center, Bracco Imaging Spa, 20811 Colleretto Giacosa, Italy.
Laszlo DézsiNanomedicine Research and Education Center, Semmelweis University, 1085 Budapest, Hungary.
Tamas FülöpNanomedicine Research and Education Center, Semmelweis University, 1085 Budapest, Hungary.
Janos SzebeniNanomedicine Research and Education Center, Semmelweis University, 1085 Budapest, Hungary.
Youssef ChahidDepartment of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands.
Kang H ZhengDepartment of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands.
Erik S G StroesDepartment of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands.
Dominique Le GuludecUniversité de Paris, UMRS1148, INSERM, F-75018 Paris, France.
François RouzetUniversité de Paris, UMRS1148, INSERM, F-75018 Paris, France.ORCID 0000-0001-6109-0087
Didier LetourneurUniversité de Paris, UMRS1148, INSERM, F-75018 Paris, France.ORCID 0000-0003-2197-9468
Inserm · FRBracco (Italy) · ITAmsterdam UMC Location University of Amsterdam · NLSemmelweis University · HUBouygues (France) · FRUniversité Paris Cité · FR

Funding

ANR ANR-13-LAB1-0005-01FP7 Health FP7-NMP-2012-LARGE-6-309820
6 · The paper itself

Abstract

The adhesion molecule P-selectin is present on the cell surface of both activated endothelium and activated platelets. The present study describes the pharmaceutical development, safety evaluation, and preclinical efficacy of a micro-dosed radiotracer. The macromolecular nanoscale assembly consisted of a natural compound made of a sulfated fucose-rich polysaccharides (fucoidan) and a radionuclide (technetium-99m) for the detection of

Indexed as

AnimalsDisease Models, AnimalDose-Response Relationship, DrugDrug DevelopmentFemaleMaleMolecular WeightMyocardial Reperfusion InjuryPolysaccharidesP-SelectinRadiopharmaceuticalsRatsRats, WistarSwineTechnetiumfucoidanPolysaccharidesP-SelectinRadiopharmaceuticalsTechnetiumGMP-grade fucoidanmolecular diagnosisregulatory toxicologyscintigraphy

Identifiers

PMID31842319
PMCPMC6949921
OpenAlexW2996465744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.