Evidence map›Paper›PMID 31842310›Full record

ArticleMarine drugs2019

Enhypyrazinones A and B, Pyrazinone Natural Products from a Marine-Derived Myxobacterium

Fan Zhang, Doug R Braun, Scott R Rajski, Don DeMaria, Tim S Bugni

Abstract read
In one paragraph

Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. 2(1RSC advances · 2023
    Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fan ZhangPharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, WI 53705, USA.
Doug R BraunPharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, WI 53705, USA.
Scott R RajskiPharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0002-0238-8411
Don DeMariaSea Samples, 369 Westshore Drive, Summerland Key, FL 33042, USA.
Tim S BugniPharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0002-4502-3084

Funding

Novel antimicrobials targeting MDR pathogens from animal microbial symbiontsU19AI142720 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI ANDES, DAVID R · 2019 to 2023
$30.1M
Metabolomics driven discovery of drug leads from symbiotic bacteriaU19AI109673 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI ANDES, DAVID R, CURRIE, CAMERON ROBERT · 2014 to 2018
$16.2M
WATER DISTRIB:PHYSICAL PROPERT:PIZZA &LMPS MOZZARELLA CHEESES:EARLY STAGE MATURP41RR002301 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN LUTE · 1985 to 2011
$13.0M
900 MHz NMR Spectrometer Biomolecular InvestigationsP41GM066326 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN L · 2002 to 2006
$5.0M
NCRR NIH HHS P41 RR002301NIAID NIH HHS U19 AI109673NIAID NIH HHS U19 AI142720NIGMS NIH HHS P41 GM066326NIH HHS U19AI109673 and U19AI142720
6 · The paper itself

Abstract

To date, studies describing myxobacterial secondary metabolites have been relatively scarce in comparison to those addressing actinobacterial secondary metabolites. This realization suggests the immense potential of myxobacteria as an intriguing source of secondary metabolites with unusual structural features and a wide array of biological activities. Marine-derived myxobacteria are especially attractive due to their unique biosynthetic gene clusters, although they are more difficult to handle than terrestrial myxobacteria. Here, we report the discovery of two new pyrazinone-type molecules, enhypyrazinones A and B, from a marine-derived myxobacterium

Indexed as

Biological ProductsIndolesMagnetic Resonance ImagingMyxococcalesPyrazinesSecondary MetabolismBiological ProductsIndolesPyrazinesEnhygromyxa sp.marine-derived myxobacteriumpyrazinone

Identifiers

PMID31842310
PMCPMC6950740

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.