ArticleAorta (Stamford, Conn.)2019
Genes Associated with Thoracic Aortic Aneurysm and Dissection: 2019 Update and Clinical Implications.
Article in Aorta (Stamford, Conn.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed.
- Undiagnosed Thoracic Aortic Aneurysms: Prevalence, Risk Factors, Screening Modalities.Deutsches Arzteblatt international · 2026Review
- Cardiac surgical outcomes and predictors of redo sternotomy in patients with Marfan syndrome: a retrospective multicentre cohort study.Open heart · 2026Article
- Review
- Clinical 4D flow MRI assessment in aortopathy-what the clinician needs to know.Cardiovascular diagnosis and therapy · 2025Review
- The Expanding Genetic Architecture of Arteriopathies: From Canonical TAAD Genes to Emerging Connective Tissue and Signaling Pathways.Medical sciences (Basel, Switzerland) · 2025Review
- Ascending aortic aneurysm and dissection risk: focus on aortic height index.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Modeling Thoracic Aortic Dissection Using Patient-Specific iPSCs Reveals VSMC Dysfunction and Extracellular Matrix Dysregulation.Stem cells international · 2025Article
- Genetic insights from a Brazilian cohort of aortopathies through targeted next-generation sequencing and FBN1 direct sequencing.Scientific reports · 2024Article
- Prevalence and Influence of Genetic Variants on Follow-Up Results in Patients Surviving Thoracic Aortic Therapy.Journal of clinical medicine · 2024Article
- Contributions of Germline and Somatic Mosaic Genetics to Thoracic Aortic Aneurysms in Nonsyndromic Individuals.Journal of the American Heart Association · 2024Article
- Marfan and Loeys-Dietz aortic phenotype: A potential tool for diagnosis and management.JTCVS open · 2024Article
- Heritable thoracic aortic disease: a literature review on genetic aortopathies and current surgical management.General thoracic and cardiovascular surgery · 2024Review
- Evaluation of the Value of Histological Examination for the Prediction of Genetic Thoracic Proximal Aortopathies.Journal of clinical medicine · 2024Article
- Prevalence of Genetic Variants and Deep Phenotyping in Patients with Thoracic Aortic Aneurysm and Dissection: A Cross-Sectional Single-Centre Cohort Study.Journal of clinical medicine · 2024Article
- Understanding genomic medicine for thoracic aortic disease through the lens of induced pluripotent stem cells.Frontiers in cardiovascular medicine · 2024Review
- Giant ascending aortic aneurysm with impending rupture as presentation of cutis laxa 1B: a case report.European heart journal. Case reports · 2023Article
- Double Heterozygous Pathogenic Variants in theGenes · 2023Article
- "Big Data" Analyses Underlie Clinical Discoveries at the Aortic Institute.The Yale journal of biology and medicine · 2023Review
- Epigenetic Reader Bromodomain-Containing Protein 4 in Aging-Related Vascular Pathologies and Diseases: Molecular Basis, Functional Relevance, and Clinical Potential.Biomolecules · 2023Review
- Comparison of Genes Associated with Thoracic and Abdominal Aortic Aneurysms.Aorta (Stamford, Conn.) · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Thoracic aortic aneurysm is a typically silent disease characterized by a lethal natural history. Since the discovery of the familial nature of thoracic aortic aneurysm and dissection (TAAD) almost 2 decades ago, our understanding of the genetics of this disorder has undergone a transformative amplification. To date, at least 37 TAAD-causing genes have been identified and an estimated 30% of the patients with familial nonsyndromic TAAD harbor a pathogenic mutation in one of these genes. In this review, we present our yearly update summarizing the genes associated with TAAD and the ensuing clinical implications for surgical intervention. Molecular genetics will continue to bolster this burgeoning catalog of culprit genes, enabling the provision of personalized aortic care.
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Registered trials
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