Evidence map›Paper›PMID 31842060›Full record

ArticlePsychosomatic medicine2020

Neural Correlates of Stress and Abdominal Obesity in Patients With Coronary Artery Disease.

Kasra Moazzami, Matthew T Wittbrodt, Bruno B Lima, Oleksiy Levantsevych, Belal Kaseer, Afif Martini, Ammer Haffar, Jonathon A Nye, Arshed A Quyyumi, Amit Shah and 2 more

Open access · greenAbstract read
In one paragraph

Article in Psychosomatic medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Stress and cardiovascular disease: an update.Nature reviews. Cardiology · 2024
    Review
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Kasra MoazzamiFrom the Department of Epidemiology (Moazzami, Lima, Levantsevych, Kaseer, Martini, Haffar, Shah, Vaccarino), Rollins School of Public Health, Emory University; Emory Clinical Cardiovascular Research Institute (Moazzami, Lima, Levantsevych, Kaseer, Martini, Haffar, Quyyumi, Shah, Vaccarino), Department of Medicine, Division of Cardiology, Emory University School of Medicine; Department of Psychiatry and Behavioral Sciences (Wittbrodt, Bremner), and Department of Radiology and Imaging Sciences (Nye, Bremner), Emory University School of Medicine, Atlanta; and Atlanta VA Medical Center (Shah, Bremner), Decatur, Gerogia.
Matthew T Wittbrodt
Bruno B Lima
Oleksiy Levantsevych
Belal Kaseer
Afif Martini
Ammer Haffar
Jonathon A Nye
Arshed A Quyyumi
Amit Shah
Viola Vaccarino
J Douglas Bremner
AID Atlanta · USBridge University · SS

Funding

Vascular Responses During Mental StressP01HL101398 · NHLBI · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 2010 to 2015
$11.0M
Mental Stress and Myocardial Ischemia after MI: Sex Differences, Mechanisms and PrognosisR01HL109413 · NHLBI · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2012 to 2023
$6.9M
Multidisciplinary Research Training to Reduce Inequities in Cardiovascular HealthT32HL130025 · NHLBI · EMORY UNIVERSITY · PI Tené T Lewis, Viola Vaccarino · 2016 to 2026
$6.4M
Neural Circuits in Women with Abuse and PTSDR01MH056120 · NIMH · YALE UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 1999 to 2011
$5.0M
Mechanisms Linking Depression to Cardiovascular RiskR01HL068630 · NHLBI · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2001 to 2010
$4.8M
PTSD and Ischemic Heart Disease Progression: A Longitudinal Twin StudyR01HL125246 · NHLBI · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2015 to 2018
$3.4M
Dopamine function, inflammation and connectivity in PTSDR01MH120262 · NIMH · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 2020 to 2023
$2.9M
Mechanisms of Depression in CVDR01HL088726 · NHLBI · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 2008 to 2012
$2.6M
Mind-Body Interactions in Cardiovascular DiseaseK24HL077506 · NHLBI · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2004 to 2013
$1.5M
Biological Correlates of Traumatic StressK24MH076955 · NIMH · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 2006 to 2013
$946k
Non-Invasive Vagal Nerve Stimulation in Patients with Opioid Use Disorders UG3DA048502 · NIDA · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS, INAN, OMER TOLGA · 2020 to 2021
$844k
Emotional Stress as a Risk Factor for Arrhythmia: Ischemic and Genetic MechanismsK23HL127251 · NHLBI · EMORY UNIVERSITY · PI SHAH, AMIT JASVANT · 2016 to 2019
$749k
NCRR NIH HHS S10 RR016917NHLBI NIH HHS K23 HL127251NHLBI NIH HHS K24 HL077506NHLBI NIH HHS P01 HL101398NHLBI NIH HHS R01 HL068630NHLBI NIH HHS R01 HL088726NHLBI NIH HHS R01 HL109413NHLBI NIH HHS R01 HL125246NHLBI NIH HHS T32 HL130025NIDA NIH HHS UG3 DA048502NIMH NIH HHS K24 MH076955NIMH NIH HHS R01 MH056120NIMH NIH HHS R01 MH120262NIMH NIH HHS T32 MH067547RRD VA I01 RX003418
6 · The paper itself

Abstract

objectiveThis study aimed to investigate the relationship between waist circumference as a measure of abdominal obesity and brain responses to stress among patients with coronary artery disease (CAD).

methodsPatients with CAD (N = 151) underwent acute mental stress tasks in conjunction with high-resolution positron emission tomography and radiolabeled water imaging of the brain. Brain responses to mental stress were correlated with waist circumference.

resultsWaist circumference was positively correlated with increased activation in the right and left frontal lobes (β values ranging from 2.81 to 3.75 in the paracentral, medial, and superior gyri), left temporal lobe, left hippocampal, left amygdala, left uncus, and left anterior and posterior cingulate gyri (β values ranging from 2.93 to 3.55). Waist circumference was also negatively associated with the left and right parietal lobes, right superior temporal gyrus, and right insula and precuneus (β values ranging from 2.82 to 5.20).

conclusionIncreased brain activation in the brain regions involved in the stress response and autonomic regulation of the cardiovascular system during psychological stress may underlie stress-induced overeating and abdominal obesity in patients with CAD.

Indexed as

AdultAgedAged, 80 and overBrainCoronary Artery DiseaseFemaleFrontal LobeGyrus CinguliHippocampusHumansMagnetic Resonance ImagingMaleMiddle AgedObesity, AbdominalParietal LobePositron-Emission Tomography

Identifiers

PMID31842060
PMCPMC7138710
OpenAlexW2996282262

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.