Evidence map›Paper›PMID 31841644›Full record

Observational studyAmerican journal of respiratory and critical care medicine2020

Females with Cystic Fibrosis Demonstrate a Differential Response Profile to Ivacaftor Compared with Males.

Katharine E Secunda, Jennifer S Guimbellot, Borko Jovanovic, Sonya L Heltshe, Scott D Sagel, Steven M Rowe, Manu Jain

Abstract readLetterObservational Study
In one paragraph

Observational study in American journal of respiratory and critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Remote analysis and management of sweat biomarkers using a wearable microfluidic sticker in adult cystic fibrosis patients.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Review
  4. Article
  5. Characterizing CFTR modulated sweat chloride response across the cf population: Initial results from the CHEC-SC study.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2023
    Article
  6. The gut-lung axis in the CFTR modulator era.Frontiers in cellular and infection microbiology · 2023
    Review
  7. Article
  8. Article
  9. Observational
  10. Article
  11. Sex differences in treatment patterns in cystic fibrosis pulmonary exacerbations.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2021
    Article
  12. Update in Pediatrics 2020.American journal of respiratory and critical care medicine · 2021
    Article
  13. Review
  14. Review
  15. The PROSPECT Is Bright for CFTR Modulators.Annals of the American Thoracic Society · 2021
    Article
  16. Caring for gender diverse youth with cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2020
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katharine E SecundaNorthwestern University Feinberg School of MedicineChicago, Illinois.
Jennifer S GuimbellotUniversity of Alabama at BirminghamBirmingham, Alabama.
Borko JovanovicNorthwestern University Feinberg School of MedicineChicago, Illinois.
Sonya L HeltsheUniversity of WashingtonSeattle, Washingtonand.
Scott D SagelChildren's Hospital Colorado and University of Colorado School of MedicineAurora, Colorado.
Steven M RoweUniversity of Alabama at BirminghamBirmingham, Alabama.
Manu JainNorthwestern University Feinberg School of MedicineChicago, Illinois.ORCID 0000-0003-1534-5629

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI David M. Bedwell · 2007 to 2026
$23.0M
Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss, Lucas R Hoffman · 2010 to 2026
$21.4M
NCATS NIH HHS UL1 TR002535NIDDK NIH HHS P30 DK072482NIDDK NIH HHS P30 DK089507
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Body WeightAdolescentAdultAge FactorsAminophenolsBody Mass IndexChildChloride Channel AgonistsChloridesCystic FibrosisDisease ProgressionFemaleForced Expiratory VolumeHumansMaleQuinolonesAminophenolsChloride Channel AgonistsChloridesivacaftorQuinolones

Identifiers

PMID31841644
PMCPMC7159427

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.