ArticleJournal of the American Chemical Society2020
Direct C-H α-Arylation of Enones with ArI(O
Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Recent Progress in Synthetic Applications of Hypervalent Iodine(III) Reagents.Chemical reviews · 2024Review
- Lewis Base-assisted Arylation of Unsaturated Carbonyls.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- 2-Fluoroenones via an Umpolung Morita-Baylis-Hillman Reaction of Enones.Organic letters · 2023Article
- Stereoselective Synthesis of Cyclobutanes by Contraction of Pyrrolidines.Journal of the American Chemical Society · 2021Article
- Formal Enone α-Arylation via I(III)-Mediated Aryl Migration/Elimination.Organic letters · 2021Article
- Recent discoveries on the structure of iodine(iii) reagents and their use in cross-nucleophile coupling.Chemical science · 2021Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
α-Arylation of α,β-unsaturated ketones constitutes a powerful synthetic transformation. It is most commonly achieved via cross-coupling of α-haloenones, but this stepwise strategy requires prefunctionalized substrates and expensive catalysts. Direct enone C-H α-arylation would offer an atom- and step-economical alternative, but such reports are scarce. Herein we report the metal-free direct C-H arylation of enones mediated by hypervalent iodine reagents. The reaction proceeds via a reductive iodonium Claisen rearrangement of in situ-generated β-pyridinium silyl enol ethers. The aryl groups are derived from ArI(O
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Registered trials
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