Observational studyPloS one2019
The microbiota composition of the offspring of patients with gestational diabetes mellitus (GDM).
Observational study in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Microbiome alterations in women with gestational diabetes mellitus and their offspring: A systematic review.Frontiers in endocrinology · 2022Pooled it
- A maternal higher-complex carbohydrate diet increases bifidobacteria and alters early life acquisition of the infant microbiome in women with gestational diabetes mellitus.Frontiers in endocrinology · 2022Trial
- Gestational diabetes and risk of type 2 diabetes: exploring the role of the gut microbiome in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).Diabetologia · 2026Article
- Gestational diabetes mellitus and maternal-infant microbiome axis: mechanistic insights and therapeutic interventions.Journal of translational medicine · 2026Review
- Maternal diabetes subtypes and offspring cutaneous health: developmental programming of sebaceous gland function in over 330,000 live births.Archives of gynecology and obstetrics · 2026Article
- Population-Level Amplicon and Metagenomic Analyses Uncover Distinct Effects of Landscape-Level Pesticides on the Maternal Gut Microbiome.Environment & health (Washington, D.C.) · 2026Article
- Gut microbiota dysbiosis, circulating microbial genetic traces, and their role in gestational diabetes.World journal of diabetes · 2026Review
- Intestinal fungal dysbiosis in gestational diabetes mellitus is associated with adverse pregnancy outcomes.BMC pregnancy and childbirth · 2026Article
- Maternal obesity, diet, and the gut microbiome: implications for offspring cardiometabolic programming.Frontiers in nutrition · 2026Review
- Programming the Infant Gut: How Maternal and Early Life Nutrition Shape the Infant Microbiome and Long-term Health-A Narrative Review.Molecular nutrition & food research · 2026Review
- Maternal consumption of urbanized diet compromises early-life health in association with gut microbiota.Gut microbes · 2025Review
- Gut Health for Two: the Critical Role of Probiotics and Prebiotics in Pregnancy and Lactation.Current nutrition reports · 2025Review
- Multiple perinatal characteristics affect the association between maternal diabetes status and early neonatal gut microbiota.mSphere · 2025Article
- Association between gestational diabetes mellitus, maternal health and diet, and gut microbiota in mother-infant dyads.BMC pregnancy and childbirth · 2025Observational
- Modulating Metabolic Health and Physiological Functions: Advances in Dietary Interventions Targeting Gut Microbiota.Therapeutics and clinical risk management · 2025Review
- Article
- The Impact of Gestational Diabetes Mellitus (GDM) on the Development and Composition of the Neonatal Gut Microbiota: A Systematic Review.Microorganisms · 2024Review
- The Gut Microbial Regulation of Epigenetic Modification from a Metabolic Perspective.International journal of molecular sciences · 2024Review
- The Association of Neonatal Gut Microbiota Community State Types with Birth Weight.Children (Basel, Switzerland) · 2024Article
- A comparison of the breast milk microbiota from women diagnosed with gestational diabetes mellitus and women without gestational diabetes mellitus.BMC pregnancy and childbirth · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The microbiota composition of the offspring of women with gestational diabetes mellitus (GDM), a common pregnancy complication, is still little known. We investigated whether the GDM offspring gut microbiota composition is associated with the maternal nutritional habits, metabolic variables or pregnancy outcomes. Furthermore, we compared the GDM offspring microbiota to the microbiota of normoglycemic-mother offspring. Fecal samples of 29 GDM infants were collected during the first week of life and assessed by 16S amplicon-based sequencing. The offspring's microbiota showed significantly lower α-diversity than the corresponding mothers. Earlier maternal nutritional habits were more strongly associated with the offspring microbiota (maternal oligosaccharide positively with infant Ruminococcus, maternal saturated fat intake inversely with infant Rikenellaceae and Ruminococcus) than last-trimester maternal habits. Principal coordinate analysis showed a separation of the infant microbiota according to the type of feeding (breastfeeding vs formula-feeding), displaying in breast-fed infants a higher abundance of Bifidobacterium. A few Bacteroides and Blautia oligotypes were shared by the GDM mothers and their offspring, suggesting a maternal microbial imprinting. Finally, GDM infants showed higher relative abundance of pro-inflammatory taxa than infants from healthy women. In conclusion, many maternal conditions impact on the microbiota composition of GDM offspring whose microbiota showed increased abundance of pro-inflammatory taxa.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.