Evidence map›Paper›PMID 31841530›Full record

ArticlePloS one2019

Towards elimination of measles and rubella in Italy: Progress and challenges.

Giovanna Adamo, Valentina Baccolini, Azzurra Massimi, Domenico Barbato, Rosario Cocchiara, Carolina Di Paolo, Annamaria Mele, Sara Cianfanelli, Aurora Angelozzi, Fulvio Castellani and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 3 institutions in 1 country.

Giovanna AdamoDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.ORCID 0000-0001-8983-1924
Valentina BaccoliniDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Azzurra MassimiDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Domenico BarbatoDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.ORCID 0000-0001-8634-0708
Rosario CocchiaraDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.ORCID 0000-0003-0787-2904
Carolina Di PaoloDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Annamaria MeleDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Sara CianfanelliDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Aurora AngelozziDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Fulvio CastellaniDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Carla SalernoDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Claudia IsonneDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Antonino BellaDepartment of Infectious Diseases, National Institute of Health, Rome, Italy.
Antonietta FiliaDepartment of Infectious Diseases, National Institute of Health, Rome, Italy.ORCID 0000-0002-9909-6422
Martina Del MansoDepartment of Infectious Diseases, National Institute of Health, Rome, Italy.
Melissa BaggieriNational Reference Laboratory for Measles and Rubella, National Institute of Health, Rome, Italy.
Loredana NicolettiNational Reference Laboratory for Measles and Rubella, National Institute of Health, Rome, Italy.
Fabio MaguranoNational Reference Laboratory for Measles and Rubella, National Institute of Health, Rome, Italy.
Stefania IannazzoInfectious Diseases and International Prophylaxis Office, Ministry of Health, Rome, Italy.
Carolina MarzuilloDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Paolo VillariDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · ITIstituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITMinistero della Salute · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn the WHO European Region, endemic transmission of measles and rubella had been interrupted by 37 and 42 of the 53 member states (MSs), respectively, by 2018. Sixteen MSs are still endemic for measles, 11 for rubella and nine for both diseases, the latter including Italy. Elimination is documented by each country's National Verification Committee (NVC) through an annual status update (ASU).

objectiveBy analysing data used to produce the ASUs, we aimed to describe the advances made by Italy towards elimination of measles and rubella. Moreover, we propose a set of major interventions that could facilitate the elimination process.

methodsA total of 28 indicators were identified within the six core sections of the ASU form and these were evaluated for the period 2013-2018. These indicators relate to the incidence of measles/rubella; epidemiological investigation of cases; investigation of outbreaks; performance of the surveillance system; population immunity levels; and implementation of supplemental immunization activities (SIAs).

resultsFrom 2013 to 2018, epidemiological and laboratory analyses of measles cases in Italy improved substantially, allowing timely investigation in 2017 and 2018 of most outbreak and sporadic cases and identification of the majority of genotypic variants. Moreover, since 2017, vaccination coverage has increased significantly. Despite these improvements, several areas of concern emerged, prompting the following recommendations: i) improve outbreak monitoring; ii) strengthen the MoRoNet network; iii) increase the number of SIAs; iv) reinforce vaccination services; v) maintain regional monitoring; vi) design effective communication strategies; vii) foster the role of general practitioners and family paediatricians.

conclusionsThe review of national ASUs is a crucial step to provide the NVC with useful insights into the elimination process and to guide the development of targeted interventions. Against this background, the seven recommendations proposed by the NVC have been shared with the Italian Ministry of Health and the Technical Advisory Group on measles and rubella elimination and have been incorporated into the new Italian Elimination Plan 2019-2023 as a technical aid to facilitate the achievement of disease elimination goals.

Indexed as

AdolescentAdultChildChild, PreschoolDisease EradicationDisease OutbreaksFemaleHumansIncidenceInfantInfant, NewbornItalyMaleMeaslesMeasles VaccineMiddle AgedMeasles Vaccine

Identifiers

PMID31841530
PMCPMC6913993
OpenAlexW2995460127

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.