Evidence map›Paper›PMID 31841397›Full record

ArticlePhysiological genomics2020

Mice lacking uterine enhancer of zeste homolog 2 have transcriptomic changes associated with uterine epithelial proliferation.

Ana M Mesa, Jiude Mao, Manjunatha K Nanjappa, Theresa I Medrano, Sergei Tevosian, Fahong Yu, Jessica Kinkade, Zhen Lyu, Yang Liu, Trupti Joshi and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Physiological genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Effects of oxycodone on placental lineages: Evidence from the transcriptome profile of mouse trophoblast giant cells.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Article
  6. Uterine-specificiScience · 2023
    Article
  7. Role of EZH2 in Uterine Gland Development.International journal of molecular sciences · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Ana M MesaDepartment of Physiological Sciences, University of Florida, Gainesville, Florida.ORCID 0000-0001-6894-9069
Jiude MaoChristopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri.
Manjunatha K NanjappaDepartment of Physiological Sciences, University of Florida, Gainesville, Florida.ORCID 0000-0001-5295-2220
Theresa I MedranoDepartment of Physiological Sciences, University of Florida, Gainesville, Florida.
Sergei TevosianDepartment of Physiological Sciences, University of Florida, Gainesville, Florida.
Fahong YuInterdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Missouri.
Jessica KinkadeChristopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri.
Zhen LyuChristopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri.
Yang LiuChristopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri.
Trupti JoshiChristopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri.
Duolin WangChristopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri.
Cheryl S RosenfeldChristopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri.ORCID 0000-0002-4137-3933
Paul S CookeDepartment of Physiological Sciences, University of Florida, Gainesville, Florida.
University of Florida · USUniversity of Missouri · USUniversity of Missouri Health System · US

Funding

Endocrine Disrupting Chemicals, Epigenetic Alterations, and Autism-Like Behaviors in the Highly Social California Mouse ModelR01ES025547 · NIEHS · UNIVERSITY OF MISSOURI-COLUMBIA · PI ROBERTS, R. MICHAEL · 2016 to 2020
$1.9M
Role of Membrane Estrogen Receptor 1 in Uterine Epithelial Response to EstrogenR21HD088006 · NICHD · UNIVERSITY OF FLORIDA · PI COOKE, PAUL S. · 2017 to 2018
$434k
Membrane estrogen receptor 1 mediation of epigenetic effects of estrogenR03HD087528 · NICHD · UNIVERSITY OF FLORIDA · PI COOKE, PAUL S. · 2016 to 2017
$166k
NICHD NIH HHS R03 HD087528NICHD NIH HHS R21 HD088006NIEHS NIH HHS R01 ES025547
6 · The paper itself

Abstract

Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that suppresses gene expression. Previously, we developed a conditional null model where EZH2 is knocked out in uterus. Deletion of uterine EZH2 increased proliferation of luminal and glandular epithelial cells. Herein, we used RNA-Seq in wild-type (WT) and EZH2 conditional knockout (

Indexed as

TranscriptomeAnimalsCell ProliferationCluster AnalysisComputational BiologyEnhancer of Zeste Homolog 2 ProteinEpigenesis, GeneticEstradiolEstrogensFemaleGene Expression ProfilingGene Expression RegulationGenotypeHeterozygoteMiceMice, KnockoutEnhancer of Zeste Homolog 2 ProteinEstradiolEstrogensEzh2 protein, mousePhosphatidylinositol 3-KinasesWnt Proteinsendometrial cancerendometriumepigeneticsestrogenfemale reproductionRNA-Sequterus

Identifiers

PMID31841397
PMCPMC7052568
OpenAlexW2996057759

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.