Evidence map›Paper›PMID 31841393›Full record

ArticleAmerican journal of physiology. Renal physiology2020

NBCe1-A is required for the renal ammonia and K

Hyun-Wook Lee, Autumn N Harris, Michael F Romero, Paul A Welling, Charles S Wingo, Jill W Verlander, I David Weiner

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Uncoupling proximal tubule ammoniagenesis from bicarbonate generation byAmerican journal of physiology. Renal physiology · 2026
    Article
  2. Article
  3. Lack of a role of NHE4 in renal ammonia metabolism.American journal of physiology. Renal physiology · 2025
    Article
  4. Role of KThe American journal of pathology · 2025
    Article
  5. Article
  6. Article
  7. Acid-base effects of combined renal deletion of NBCe1-A and NBCe1-B.American journal of physiology. Renal physiology · 2022
    Article
  8. Role of the renal androgen receptor in sex differences in ammonia metabolism.American journal of physiology. Renal physiology · 2021
    Article
  9. Sex differences in renal ammonia metabolism.American journal of physiology. Renal physiology · 2021
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Hyun-Wook LeeDivision of Nephrology, Hypertension and Renal Transplantation, University of Florida College of Medicine, Gainesville, Florida.
Autumn N HarrisDivision of Nephrology, Hypertension and Renal Transplantation, University of Florida College of Medicine, Gainesville, Florida.ORCID 0000-0002-2329-3905
Michael F RomeroDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.
Paul A WellingNephrology Division, Departments of Medicine and Physiology, Johns Hopkins Medical School, Baltimore, Maryland.
Charles S WingoDivision of Nephrology, Hypertension and Renal Transplantation, University of Florida College of Medicine, Gainesville, Florida.
Jill W VerlanderDivision of Nephrology, Hypertension and Renal Transplantation, University of Florida College of Medicine, Gainesville, Florida.ORCID 0000-0002-4096-4897
I David WeinerDivision of Nephrology, Hypertension and Renal Transplantation, University of Florida College of Medicine, Gainesville, Florida.ORCID 0000-0002-0046-0600
University of Florida · USVeterans Health Administration · USJohns Hopkins University · USMayo Clinic · US

Funding

WNK-SPAK signaling in the Distal NephronR01DK093501 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire, Paul A Welling · 2012 to 2026
$12.1M
Southeast Resource Center for Integrated Metabolomics (SECIM)U24DK097209 · NIDDK · UNIVERSITY OF FLORIDA · PI EDISON, ARTHUR S, YOST, RICHARD A. · 2013 to 2017
$9.2M
Molecular of ROMK Channel FunctionR01DK054231 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI Paul A Welling · 1998 to 2026
$7.7M
OXGR1 in Renal Intercalated Cells, Salt Transport and Diuretic EfficacyR01DK110375 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire, SUSAN MARIE WALL · 2017 to 2026
$6.7M
H/HCO3 transport in the collecting ductR01DK045788 · NIDDK · UNIVERSITY OF FLORIDA · PI WEINER, I. DAVID · 2000 to 2017
$4.4M
Molecular Mechanisms Regulating Ammonia MetabolismR01DK107798 · NIDDK · UNIVERSITY OF FLORIDA · PI WEINER, I. DAVID · 2016 to 2025
$3.2M
Sex Differences in Renal Ammonia MetabolismK08DK120873 · NIDDK · UNIVERSITY OF FLORIDA · PI HARRIS, AUTUMN N · 2019 to 2023
$952k
Console upgrade for microimaging and solid state NMR spectroscopy at 600 MHzS10RR031637 · NCRR · UNIVERSITY OF FLORIDA · PI LONG, JOANNA R · 2011 to 2011
$450k
NCRR NIH HHS S10 RR031637NIDDK NIH HHS K08 DK120873NIDDK NIH HHS R01 DK045788NIDDK NIH HHS R01 DK054231NIDDK NIH HHS R01 DK093501NIDDK NIH HHS R01 DK107798NIDDK NIH HHS R01 DK110375NIDDK NIH HHS U24 DK097209
6 · The paper itself

Abstract

Hypokalemia increases ammonia excretion and decreases K

Indexed as

Renal EliminationAcidosisAldosteroneAmmoniaAnimalsBiomarkersDisease Models, AnimalEpithelial Sodium ChannelsGlutamate-Ammonia LigaseH(+)-K(+)-Exchanging ATPaseHypokalemiaKidney Tubules, ProximalMice, KnockoutPhosphorylationPotassium, DietarySodium-Bicarbonate SymportersAldosteroneAmmoniaBiomarkersEpithelial Sodium ChannelsGlul protein, mouseGlutamate-Ammonia LigaseH(+)-K(+)-Exchanging ATPasePotassium, DietarySlc12a3 protein, mouseSlc4a4 protein, mouseSodium-Bicarbonate SymportersSolute Carrier Family 12, Member 3ammoniapotassiumproximal tubule

Identifiers

PMID31841393
PMCPMC7052652
OpenAlexW2994970876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.