Evidence map›Paper›PMID 31841392›Full record

ArticleAmerican journal of physiology. Renal physiology2020

Soluble (pro)renin receptor regulation of ENaC involved in aldosterone signaling in cultured collecting duct cells.

Fei Wang, Renfei Luo, Kexin Peng, Xiyang Liu, Chuanming Xu, Xiaohan Lu, Sunhapas Soodvilai, Tianxin Yang

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Fei WangDepartment of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah.
Renfei LuoDepartment of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah.
Kexin PengDepartment of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah.
Xiyang LiuInstitute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Chuanming XuDepartment of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah.
Xiaohan LuDepartment of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah.
Sunhapas SoodvilaiDepartment of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Tianxin YangDepartment of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah.
University of Utah · USSun Yat-sen University · CNMahidol University · TH

Funding

Interaction of PGE2 and intrarenal RAS in AngII-induced hypertensionR01DK104072 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI YANG, TIANXIN · 2015 to 2025
$3.7M
Role of (pro)renin receptor in aldosterone signaling in the kidneyR01HL139689 · NHLBI · UNIVERSITY OF UTAH · PI YANG, TIANXIN · 2018 to 2021
$2.3M
Interaction of (pro)renin receptor and PPARy in regulation of plasma volumeR01HL135851 · NHLBI · UNIVERSITY OF UTAH · PI YANG, TIANXIN · 2017 to 2021
$2.3M
BLRD VA IK6 BX005223NHLBI NIH HHS R01 HL135851NHLBI NIH HHS R01 HL139689NIDDK NIH HHS R01 DK104072
6 · The paper itself

Abstract

We have previously shown that activation of (pro)renin receptor (PRR) induces epithelial Na

Indexed as

Epithelial Sodium ChannelsAldosteroneAnimalsBiological TransportCells, CulturedElectrophysiological PhenomenaEpithelial Sodium Channel BlockersKidney Tubules, CollectingMaleNADPH Oxidase 4Prorenin ReceptorRatsRats, Sprague-DawleyReceptors, Cell SurfaceSignal TransductionSodiumAldosteroneEpithelial Sodium Channel BlockersEpithelial Sodium ChannelsNADPH Oxidase 4Nox4 protein, ratProrenin ReceptorReceptors, Cell SurfaceSodiumcollecting ductepithelial Na+ channel activation(pro)renin receptorsite-1 protease

Identifiers

PMID31841392
PMCPMC7099505
OpenAlexW2995282083

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.