Evidence map›Paper›PMID 31841318›Full record

ArticleChemical research in toxicology2020

Modulation of

Pennapa Thongararm, Bogdan I Fedeles, Sakunchai Khumsubdee, Amanda L Armijo, Lina Kim, Apinya Thiantanawat, Jeerawan Promvijit, Panida Navasumrit, Mathuros Ruchirawat, Robert G Croy and 1 more

Open access · greenAbstract read
In one paragraph

Article in Chemical research in toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Pennapa ThongararmDepartments of Biological Engineering and Chemistry, and Center for Environmental Health Sciences , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.
Bogdan I FedelesDepartments of Biological Engineering and Chemistry, and Center for Environmental Health Sciences , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.
Sakunchai KhumsubdeeDepartments of Biological Engineering and Chemistry, and Center for Environmental Health Sciences , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.
Amanda L ArmijoDepartments of Biological Engineering and Chemistry, and Center for Environmental Health Sciences , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.
Lina KimDepartments of Biological Engineering and Chemistry, and Center for Environmental Health Sciences , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.
Apinya ThiantanawatChulabhorn Research Institute , Bangkok 10210 , Thailand.
Jeerawan PromvijitChulabhorn Research Institute , Bangkok 10210 , Thailand.
Panida NavasumritChulabhorn Research Institute , Bangkok 10210 , Thailand.
Mathuros RuchirawatChulabhorn Research Institute , Bangkok 10210 , Thailand.
Robert G CroyDepartments of Biological Engineering and Chemistry, and Center for Environmental Health Sciences , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.
John M EssigmannDepartments of Biological Engineering and Chemistry, and Center for Environmental Health Sciences , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.ORCID 0000-0002-2196-5691
Center for Environmental Health · USChulabhorn Research Institute · TH

Funding

TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YAFFE, MICHAEL B · 1985 to 2020
$25.6M
The MIT Superfund Research Program: A Systems Approach for the Protection of Human Health from Hazardous ChemicalsP42ES027707 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Desiree Plata · 2017 to 2026
$22.2M
TRAINING GRANTS IN ENVIROMENTAL TOXICOLOGYT32ES007020 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 1985 to 2024
$13.1M
Intra and Extra-Chromosomal Probes for Mutagenesis by CarcinogensR01CA080024 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 1998 to 2025
$5.9M
NCI NIH HHS R01 CA080024NIEHS NIH HHS P30 ES002109NIEHS NIH HHS P42 ES027707NIEHS NIH HHS T32 ES007020NIEHS NIH HHS Y02 ES007020
6 · The paper itself

Abstract

DNA methylating agents are abundant in the environment and are sometimes used in cancer chemotherapy. They react with DNA to form methyl-DNA adducts and byproduct lesions that can be both toxic and mutagenic. Foremost among the mutagenic lesions is

Indexed as

Alkylating AgentsAnimalsDNA Modification MethylasesDNA Repair EnzymesEnzyme InhibitorsFibroblastsMethylnitrosoureaMiceMice, Inbred C57BLMice, TransgenicMutagenesisTumor Suppressor ProteinsAlkylating AgentsDNA Modification MethylasesDNA Repair EnzymesEnzyme InhibitorsMethylnitrosoureaMGMT protein, mouseTumor Suppressor Proteins

Identifiers

PMID31841318
PMCPMC7033946
OpenAlexW2995463665

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.