Evidence map›Paper›PMID 31841217›Full record

SynthesisEuropean journal of immunology2020

cDC2 and plasmacytoid dendritic cells diminish from tissues of patients with non-Hodgkin orbital lymphoma and idiopathic orbital inflammation.

Kamil G Laban, Rianne Rijken, Sanne Hiddingh, Jorre S Mertens, Rob L P van der Veen, Christine A E Eenhorst, Aridaman Pandit, Timothy R D J Radstake, Joke H de Boer, Rachel Kalmann and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Kamil G LabanOphthalmo-Immunology Unit, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-8817-371X
Rianne RijkenLaboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Sanne HiddinghOphthalmo-Immunology Unit, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Jorre S MertensLaboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Rob L P van der VeenDepartment of Ophthalmology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Christine A E EenhorstDepartment of Ophthalmology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Aridaman PanditLaboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0003-2057-9737
Timothy R D J RadstakeOphthalmo-Immunology Unit, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Joke H de BoerOphthalmo-Immunology Unit, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Rachel KalmannOphthalmo-Immunology Unit, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Jonas J W KuiperOphthalmo-Immunology Unit, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Utrecht University · NLRadboud University Nijmegen · NL

Funding

Dr. F.P. Fischer-Stichting FS2016-1Rotterdamse Stichting Blindenbelangen Een nieuwe bloedtest voor het detecteren van oogkaStichting Ankie HakStichting Lijf en Leven Een nieuwe bloedtest voor het detecteren van oogka
6 · The paper itself

Abstract

Non-Hodgkin orbital lymphoma (NHOL) and idiopathic orbital inflammation (IOI) are common orbital conditions with largely unknown pathophysiology. To investigate the immune cell composition of these diseases, we performed standardized 29 parameter flow cytometry phenotyping in peripheral blood mononuclear cells of 18 NHOL patients, 21 IOI patients, and 41 unaffected controls. Automatic gating by FlowSOM revealed decreased abundance of meta-clusters containing dendritic cells in patients, which we confirmed by manual gating. A decreased percentage of (HLA-DR

Indexed as

AdultCell DifferentiationCohort StudiesCytokinesDendritic CellsFemaleHLA-DR AntigensHumansInflammationLymphoma, Non-HodgkinMaleMiddle AgedOrbitOrbital NeoplasmsTh2 CellsCytokinesHLA-DR AntigenscDC2FlowSOMidiopathic orbital inflammationnon-Hodgkin orbital lymphomaplasmacytoid dendritic cells

Identifiers

PMID31841217
PMCPMC7187234
OpenAlexW2995441784

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.