Evidence map›Paper›PMID 31841111›Full record

ArticleeLife2019

James Chen, Saumya Gopalkrishnan, Courtney Chiu, Albert Y Chen, Elizabeth A Campbell, Richard L Gourse, Wilma Ross, Seth A Darst

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 80 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Structural principles of transcriptional collisions.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Real-time capture of σNature communications · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

James ChenThe Rockefeller University, New York, United States.ORCID 0000-0002-2311-003X
Saumya GopalkrishnanDepartment of Bacteriology, University of Wisconsin-Madison, Madison, United States.
Courtney ChiuThe Rockefeller University, New York, United States.
Albert Y ChenDepartment of Bacteriology, University of Wisconsin-Madison, Madison, United States.
Elizabeth A CampbellThe Rockefeller University, New York, United States.
Richard L GourseDepartment of Bacteriology, University of Wisconsin-Madison, Madison, United States.
Wilma RossDepartment of Bacteriology, University of Wisconsin-Madison, Madison, United States.
Seth A DarstThe Rockefeller University, New York, United States.ORCID 0000-0002-8241-3153
Rockefeller University · USUniversity of Wisconsin–Madison · US

Funding

Structure, function, and regulation of the bacterial transcription cycleR35GM118130 · NIGMS · ROCKEFELLER UNIVERSITY · PI DARST, SETH A. · 2016 to 2025
$8.9M
MEDCHANISM, ACTIVATION, &CONTROL OF RRNA TRANSCRIPTIONR01GM037048 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI GOURSE, RICHARD L. · 1986 to 2020
$5.9M
Structure/function analyses of essential mycobacterial transcription regulatorsR01GM114450 · NIGMS · ROCKEFELLER UNIVERSITY · PI CAMPBELL, ELIZABETH A · 2015 to 2023
$3.4M
NIGMS NIH HHS R01 GM037048NIGMS NIH HHS R01 GM114450NIGMS NIH HHS R35 GM118130NIH HHS R01 GM114450NIH HHS R01 GM37048NIH HHS R35 GM118130
6 · The paper itself

Abstract

TraR and its homolog DksA are bacterial proteins that regulate transcription initiation by binding directly to RNA polymerase (RNAP) rather than to promoter DNA. Effects of TraR mimic the combined effects of DksA and its cofactor ppGpp, but the structural basis for regulation by these factors remains unclear. Here, we use cryo-electron microscopy to determine structures of

Indexed as

Nucleic Acid ConformationBase SequenceCarrier ProteinsCryoelectron MicroscopyDNA, BacterialDNA-Directed RNA PolymerasesEscherichia coliEscherichia coli ProteinsModels, MolecularMutagenesis, Site-DirectedPromoter Regions, GeneticProtein ConformationRNA, BacterialTranscriptional ActivationTranscription FactorsTranscription Initiation, GeneticCarrier ProteinsdksA protein, E coliDNA, BacterialDNA-Directed RNA PolymerasesEscherichia coli ProteinsRNA, BacterialTranscription FactorsTraR protein, E colibiochemistrychemical biologycryo-electron microscopyE. colimolecular biophysicsRNA polymerasestructural biologytranscription initiationTraR

Identifiers

PMID31841111
PMCPMC6970531
OpenAlexW2996650908

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.