Evidence map›Paper›PMID 31841044›Full record

ArticleAmerican journal of respiratory and critical care medicine2020

Etiology, Risk Factors, and Biomarkers in Systemic Sclerosis with Interstitial Lung Disease.

Dinesh Khanna, Donald P Tashkin, Christopher P Denton, Elisabetta A Renzoni, Sujal R Desai, John Varga

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 2 pooled it
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 2 syntheses or guidelines pooled it, 187 citations in OpenAlex.

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  13. ICOSMolecular medicine (Cambridge, Mass.) · 2026
    Article
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  15. Proceedings of the 2Mediterranean journal of rheumatology · 2026
    Article
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58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 2 countries.

Dinesh KhannaDivision of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, Ann Arbor, Michigan.
Donald P TashkinDepartment of Medicine, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California.
Christopher P DentonUniversity College London Centre for Rheumatology and Connective Tissue Diseases, Royal Free Hospital, London, United Kingdom.
Elisabetta A RenzoniInterstitial Lung Disease Unit and.
Sujal R DesaiNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
John VargaNorthwestern Scleroderma Program, Feinberg School of Medicine, Chicago, Illinois.
National Health Service · GBNational Institute for Health Research · GBScleroderma Foundation · USThe Royal Free Hospital · GBUniversity of California, Los Angeles · USUniversity of Michigan · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic sclerosis (SSc) is a complex, multiorgan, autoimmune disease. Lung fibrosis occurs in ∼80% of patients with SSc; 25% to 30% develop progressive interstitial lung disease (ILD). The pathogenesis of fibrosis in SSc-associated ILD (SSc-ILD) involves cellular injury, activation/differentiation of mesenchymal cells, and morphological/biological changes in epithelial/endothelial cells. Risk factors for progressive SSc-ILD include older age, male sex, degree of lung involvement on baseline high-resolution computed tomography imaging, reduced Dl

Indexed as

CurriculumAdultAgedAged, 80 and overBiomarkersEducation, Medical, ContinuingFemaleGenetic Predisposition to DiseaseHumansLung Diseases, InterstitialMaleMiddle AgedRisk FactorsScleroderma, SystemicBiomarkersautoimmune diseasesbiomarkersinterstitial lung diseasesrisk factorssystemic sclerosis

Identifiers

PMID31841044
PMCPMC7068837
OpenAlexW2995067265

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.