ArticleZoological research2020
Neuroprotectants attenuate hypobaric hypoxia-induced brain injuries in cynomolgus monkeys.
Erratum issuedOpen access · diamondAbstract read
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Article in Zoological research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
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13citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
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- A Synthetic Steroid 5α-Androst-3β, 5, 6β-triol Alleviates Radiation-Induced Brain Injury in Mice via Inhibiting GBP5/NF-κB/NLRP3 Signal Axis.Molecular neurobiology · 2024Article
- Comparative transcriptome analysis between rhesus macaques (Zoological research · 2024Article
- Bloodletting Acupuncture at Jing-Well Points on Hand Induced Autophagy to Alleviate Brain Injury in Acute Altitude Hypoxic Rats by Activating PINK1/Parkin Pathway.Chinese journal of integrative medicine · 2023Article
- Mechanism, prevention and treatment of cognitive impairment caused by high altitude exposure.Frontiers in physiology · 2023Review
- Altered excitability of motor neuron pathways after stroke: more than upper motor neuron impairments.Stroke and vascular neurology · 2022Article
- Comprehensive annotation of the Chinese tree shrew genome by large-scale RNA sequencing and long-read isoform sequencing.Zoological research · 2021Article
- Establishment of a hypobaric hypoxia-induced cell injury model in PC12 cells.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2021Article
- Author Correction: Neuroprotectants attenuate hypobaric hypoxia-induced brain injuries in cynomolgus monkeys.Zoological research · 2021Article
- The forty-year journey ofZoological research · 2021Article
- SMARCB1 Promotes Ubiquitination and Degradation of NR4A3 via Direct Interaction Driven by ROS in Vascular Endothelial Cell Injury.Oxidative medicine and cellular longevity · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
27 authors at 5 institutions in 3 countries.
Pei ZhangState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.
Jie-Si ChenDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.
Qi-Ye LiBGI-Shenzhen, Shenzhen, Guangdong 518083, China.
Long-Xiang ShengDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.
Yi-Xing GaoInstitute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China.
Bing-Zheng LuDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.
Wen-Bo ZhuDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.
Xiao-Yu ZhanBGI-Shenzhen, Shenzhen, Guangdong 518083, China.
Yuan LiDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.
Zhi-Bing YuanInstitute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China.
Gang XuInstitute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China.
Bi-Tao QiuSection for Ecology and Evolution, Department of Biology, University of Copenhagen, Copenhagen DK-2100, Denmark.
Min YanDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.
Chun-Xue GuoBGI-Shenzhen, Shenzhen, Guangdong 518083, China.
You-Qiong WangDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.
Yi-Jun HuangDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.
Jing-Xia ZhangSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong 510006, China.
Fu-Yu LiuInstitute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China.
Zhong-Wei TangInstitute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China.
Sui-Zhen LinGuangzhou Cellprotek Pharmaceutical Co. Ltd., Guangzhou, Guangdong 510663, China.
David N. CooperInstitute of Medical Genetics, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Huan-Ming YangBGI-Shenzhen, Shenzhen, Guangdong 518083, China.
Jian WangBGI-Shenzhen, Shenzhen, Guangdong 518083, China.
Yu-Qi GaoInstitute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China.
Wei YinDepartment of Biochemistry, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China. E-mail: yinwei@mail.sysu.edu.cn.
Guo-Jie ZhangState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.
Guang-Mei YanDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China. E-mail: ygm@mail.sysu.edu.cn.
Sun Yat-sen University · CNArmy Medical University · CNBGI Group (China) · CNUniversity of Copenhagen · DKCardiff University · GB
Funding
Carlsberg Foundation Grant CF16-0663D Team Program of Guangdong Province 2013Y104Introduction of Innovative R&D Team Program of Guangdong Province 2013Y104Key Projects of the Military Science and Technology PLA AWS14C007 and AWS16J023Leading Talent Project in Science and Technology of Guangzhou Development District 2019-L002Lundbeck Foundation Grant R190-2014-2827National Major Scientific and Technological Special Project for "Significant New Drugs Development" 2016ZX09101026National Major Scientific and Technological Special Project for"Significant New Drugs Development" 2016ZX09101026National Natural Science Foundation of China 81773711Science and Technology Program of Guangzhou, China 201704020103Strategic Priority Research Program of the Chinese Academy of Sciences XDB13000000the National Natural Science Foundation of China 81773711
Abstract
Hypobaric hypoxia (HH) exposure can cause serious brain injury as well as life-threatening cerebral edema in severe cases. Previous studies on the mechanisms of HH-induced brain injury have been conducted primarily using non-primate animal models that are genetically distant to humans, thus hindering the development of disease treatment. Here, we report that cynomolgus monkeys (
Indexed as
Macaca fascicularisTranscriptomeAndrostanolsAnimalsBrain DiseasesCalciumGene Expression RegulationHypoxiaLeukocytesMaleMonkey DiseasesNeuroprotective AgentsPressureProgesteroneandrost-3,5,6-triolAndrostanolsCalciumNeuroprotective AgentsProgesteroneAcute hypobaric hypoxiaBrain injuryCynomolgus monkeysGene regulatory networksNeuroprotectant
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