Evidence map›Paper›PMID 31840920›Full record

ArticleTransboundary and emerging diseases2020

Emergence of West Nile virus lineage 2 in Europe: Characteristics of the first seven cases of West Nile neuroinvasive disease in horses in Austria.

Phebe de Heus, Jolanta Kolodziejek, Jeremy V Camp, Katharina Dimmel, Zoltán Bagó, Zdenek Hubálek, René van den Hoven, Jessika-M V Cavalleri, Norbert Nowotny

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Transboundary and emerging diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
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  6. Cellular Immune Response in Horses After West Nile Neuroinvasive Disease.Animals : an open access journal from MDPI · 2025
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  7. Detection of West Nile virus via retrospective mosquito arbovirus surveillance, United Kingdom, 2025.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 5 countries.

Phebe de HeusSection Equine Internal Medicine, University Equine Hospital, University of Veterinary Medicine Vienna, Vienna, Austria.
Jolanta KolodziejekViral Zoonoses, Emerging and Vector-Borne Infections Group, Institute of Virology, University of Veterinary Medicine Vienna, Vienna, Austria.
Jeremy V CampViral Zoonoses, Emerging and Vector-Borne Infections Group, Institute of Virology, University of Veterinary Medicine Vienna, Vienna, Austria.
Katharina DimmelViral Zoonoses, Emerging and Vector-Borne Infections Group, Institute of Virology, University of Veterinary Medicine Vienna, Vienna, Austria.
Zoltán BagóInstitute for Veterinary Disease Control Mödling, Austrian Agency for Health and Food Safety Ltd (AGES), Mödling, Austria.
Zdenek HubálekInstitute of Vertebrate Biology, Czech Academy of Sciences, Brno, Czech Republic.
René van den HovenSection Equine Internal Medicine, University Equine Hospital, University of Veterinary Medicine Vienna, Vienna, Austria.
Jessika-M V CavalleriSection Equine Internal Medicine, University Equine Hospital, University of Veterinary Medicine Vienna, Vienna, Austria.
Norbert NowotnyViral Zoonoses, Emerging and Vector-Borne Infections Group, Institute of Virology, University of Veterinary Medicine Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0002-3548-571X
University of Veterinary Medicine Vienna · ATAustrian Agency for Health and Food Safety · ATCzech Academy of Sciences, Institute of Vertebrate Biology · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report details of the first seven equine cases of confirmed West Nile neuroinvasive disease in Austria. The cases presented during summer and autumn of 2016 (n = 2), 2017 (n = 3) and 2018 (n = 2). All horses showed gait abnormalities and 6 of 7 horses exhibited fasciculations and/or tremors, and we provide video recordings of these. Three horses also showed cranial nerve involvement. Following rapid improvement, three horses were discharged. Four horses were euthanized due to the severity of clinical signs and subjected to neuropathological examination. West Nile virus (WNV) lineage 2 nucleic acid was detected in 5 of 7 horses, and WNV-specific neutralizing antibodies in all 7 horses. In addition, serologic evidence of WNV infection was found in two out of fourteen in-contact horses. Horses may be considered a sentinel species for human WNV infections, integrating human and veterinary medicine and thus contributing to the one health concept.

Indexed as

AnimalsAustriaFatal OutcomeFemaleHorse DiseasesHorsesMaleSentinel SpeciesWest Nile FeverWest Nile virusAustriaequidflavivirushorseWest Nile neuroinvasive diseaseWest Nile viruszoonosis

Identifiers

PMID31840920
PMCPMC7317211
OpenAlexW2995058815

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.