Evidence map›Paper›PMID 31840755›Full record

ArticleJournal of public health (Oxford, England)2020

Effect of an intensive lifestyle intervention on the prevalence of metabolic syndrome and its components among overweight and obese adults.

M Guzmán, E Zbella, S Shah Alvarez, J L Nguyen, E Imperial, F J Troncale, C Holub, A K Mallhi, S VanWyk

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of public health (Oxford, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03588117 completednot on this map

Impact of Physician-supervised Nonsurgical Weight Management Program on Metabolic Syndrome

TypeobservationalSponsorMedi-Weightloss Franchising USA, LLCRan2015 to 2017Enrolled479ConditionsMetabolic SyndromeArmsPhysician-supervised nonsurgical weight management program
NCT06768892 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Workplace Weight Control Program: Combating Obesity in a Multinational Factory in Egypt.

TypeobservationalSponsorTanta UniversityRan2025 to 2025Enrolled154ConditionsObesity and Obesity-related Medical ConditionsArmsDietary Intervention, Cognitive Behavioral Therapy (CBT), Physical exercise training
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Metabolic syndrome exacerbates amyloid pathology in a comorbid Alzheimer's mouse model.Biochimica et biophysica acta. Molecular basis of disease · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

M GuzmánDivision of Research & Development, Department of Medical Affairs, Medi-Weightloss, 509 South Hyde Park Avenue, Tampa, FL 33606, USA.
E ZbellaFlorida Fertility Institute, 2454 N. McMullen Booth Road Suite 601, Clearwater, FL 33759, USA.
S Shah AlvarezDepartment of Medical Affairs, Medi-Weightloss, 509 South Hyde Park Avenue, Tampa, FL 33606, USA.
J L NguyenDepartment of Pharmacy Practice, College of Pharmacy, Mercer University, 3001 Mercer University Drive, Atlanta, GA 30341, USA.
E ImperialIredell Primary Care for Women, 114 Gateway Blvd, Suite B, Mooresville, NC 28117, USA.
F J TroncaleSection of Gastroenterology, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06510, USA.
C HolubDepartment of Public Health, College of Education, Health and Human Services, California State University, 333 S. Twin Oaks Valley Road, San Marcos, CA 92096, USA.
A K MallhiDivision of Research & Development, Department of Medical Affairs, Medi-Weightloss, 509 South Hyde Park Avenue, Tampa, FL 33606, USA.
S VanWykIndependent Consultant, 2518 69th Ave S, St. Petersburg, FL 33712, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite the fact that up to a third of the global population has metabolic syndrome (MetS), it has been overlooked in clinical settings. This study assesses the impact of a physician-supervised nonsurgical weight management program on the prevalence of MetS and its key indicators.

methodsFour-hundred seventy-nine overweight and obese participants aged 19 years or older were included in a prospective longitudinal study. Changes in MetS and its key indicators were assessed using the binomial exact, chi-square and Wilcoxon signed-rank tests in an intent-to-treat study population. Differences in age strata were assessed using a generalized linear model.

resultsFifty-two percent of participants (n = 249) had MetS at baseline. Prevalence of MetS decreased steadily with significant changes from baseline observed at weeks 13 (31.8%, P < 0.0001), 26 (28.7%, P < 0.0012) and 39 (21.6%, P < 0.0002); changes from baseline were observed at week 52 as statistically significant (16.7%, P < 0.0012). Improvements in anthropometrics and levels of key indicators of MetS were observed throughout the study.

conclusionThese findings confirm that weight loss is inversely associated with prevalence of MetS and its key indicators among overweight and obese individuals. Future studies may benefit from a larger sample size and better retention (ClinicalTrials.gov ID: NCT03588117).

Indexed as

Metabolic SyndromeAdultHumansLife StyleLongitudinal StudiesObesityOverweightPrevalenceProspective StudiesRisk Factorschronic diseaseobesity

Identifiers

PMID31840755
PMCPMC7685849

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.