ReviewThe Journal of international medical research2020
Challenges in early identification of causes and treatment of cholestasis in patients with hyperthyroidism: a case report and literature review.
Review in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 10 citations in OpenAlex.
- Interplay between endocrine disorders and liver dysfunction: Mechanisms of damage and therapeutic approaches.World journal of gastroenterology · 2025Review
- Predictors of poor prognosis in long-term survivors of differentiated thyroid cancer with psychiatric disorders.World journal of psychiatry · 2025Article
- Liver Dysfunction in a Patient with Graves' Disease.Journal of clinical medicine · 2024Review
- Graves' disease associated with cholestatic jaundice and persistent diarrhoea.BMJ case reports · 2021Article
- [Intrahepatic Cholestasis and Hyperbilirubinemia Induced by Hyperthyroi- dism: A Case Series].Acta gastroenterologica LatinoamericanaArticle
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
Early identification of the causes of cholestasis is important for appropriate management of patients with hyperthyroidism. We report a patient who had hyperthyroidism and severe cholestasis after methimazole (MMI) treatment. The patient was diagnosed as having MMI-induced cholestatic hepatitis. Treatment with MMI was stopped at admission to hospital. However, his serum total bilirubin (TBil) level rose from 410.5 µmol/L to 519.9 µmol/L and prothrombin time activity (PTA) dropped from 81.0% to 52.2% in 10 days. To prevent further deterioration of his liver function, plasma exchange was performed three times, and dexamethasone (10 mg, intravenously) was used each time. His PTA rose to 101% and his TBil continued to increase to 669.8 µmol/L after plasma exchange. He was subsequently diagnosed as having thyrotoxicosis-induced cholestasis and treated with radioactive iodine (380 MBq) 2 weeks after admission. His hyperthyroidism was significantly relieved, but the TBil level further increased to 776.8 µmol/L. Three weeks after admission, oral prednisone (30 mg/day) was used in this patient. Subsequently, his TBil levels gradually decreased and his liver function almost normalized within 3 months. We discuss the literature on cholestasis in the context of hyperthyroidism.
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