Evidence map›Paper›PMID 31840521›Full record

ArticleMolecular pharmaceutics2020

Cellular Delivery of Bioorthogonal Pretargeting Therapeutics in PSMA-Positive Prostate Cancer.

Sudath Hapuarachchige, Colin T Huang, Madeline C Donnelly, Cyril Bařinka, Shawn E Lupold, Martin G Pomper, Dmitri Artemov

Open access · greenAbstract read
In one paragraph

Article in Molecular pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

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  18. Enhancing the therapeutic index of [Nuclear medicine and biology
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Sudath HapuarachchigeThe Russell H. Morgan Department of Radiology and Radiological Science , The Johns Hopkins University School of Medicine , 720 Rutland Avenue , Baltimore , Maryland 21205 , United States.ORCID 0000-0002-1166-8247
Colin T HuangThe Russell H. Morgan Department of Radiology and Radiological Science , The Johns Hopkins University School of Medicine , 720 Rutland Avenue , Baltimore , Maryland 21205 , United States.
Madeline C DonnellyThe Russell H. Morgan Department of Radiology and Radiological Science , The Johns Hopkins University School of Medicine , 720 Rutland Avenue , Baltimore , Maryland 21205 , United States.
Cyril BařinkaLaboratory of Structural Biology , Institute of Biotechnology of the Czech Academy of Sciences , Prumyslova 595 , Vestec 252 50 , Czech Republic.ORCID 0000-0003-2751-3060
Shawn E LupoldThe James Buchanan Brady Urologic Institute and Department of Urology , Johns Hopkins School of Medicine , 600 N. Wolfe St. , Baltimore , Maryland 21287 , United States.
Martin G PomperThe Russell H. Morgan Department of Radiology and Radiological Science , The Johns Hopkins University School of Medicine , 720 Rutland Avenue , Baltimore , Maryland 21205 , United States.ORCID 0000-0001-6753-3010
Dmitri ArtemovThe Russell H. Morgan Department of Radiology and Radiological Science , The Johns Hopkins University School of Medicine , 720 Rutland Avenue , Baltimore , Maryland 21205 , United States.
Johns Hopkins University · USCzech Academy of Sciences · CZ

Funding

Training/Dissemination-Resource for Molecular Imaging Agents in Precision MedicineP41EB024495 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MARTIN G POMPER · 2017 to 2026
$11.8M
PSMA-based Cancer Imaging AgentsR01CA134675 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI POMPER, MARTIN G · 2009 to 2025
$6.2M
Small Molecule PSMA-Targeted Alpha TherapyR01CA184228 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI POMPER, MARTIN G, ZALUTSKY, MICHAEL ROD · 2014 to 2023
$3.6M
HER2-pretargeting image-guided therapy of breast cancerR01CA209884 · NCI · JOHNS HOPKINS UNIVERSITY · PI ARTEMOV, DMITRI · 2017 to 2021
$2.0M
NCI NIH HHS R01 CA134675NCI NIH HHS R01 CA184228NCI NIH HHS R01 CA209884NIBIB NIH HHS P41 EB024495
6 · The paper itself

Abstract

Prostate cancer is primarily fatal after it becomes metastatic and castration-resistant despite novel combined hormonal and chemotherapeutic regimens. Hence, new therapeutic concepts and drug delivery strategies are urgently needed for the eradication of this devastating disease. Here we report the highly specific,

Indexed as

AlbuminsAntibodies, MonoclonalAntigens, SurfaceAntineoplastic Agents, PhytogenicCell Line, TumorCell SurvivalClick ChemistryCyclooctanesDrug Delivery SystemsFluorobenzenesGlutamate Carboxypeptidase IIHumansImmunoglobulin Fab FragmentsMaleMaytansineNanomedicineAlbuminsAlexaFluor 488 carboxylic acid tetrafluorophenyl esterAntibodies, MonoclonalAntigens, SurfaceAntineoplastic Agents, PhytogenicCyclooctanesFluorobenzenesFOLH1 protein, humanGlutamate Carboxypeptidase IIImmunoglobulin Fab FragmentsMaytansineTubulin Modulatorsbioorthogonal click chemistrydrug deliverynanomedicinepretargeted therapyPSMA(+) prostate cancer

Identifiers

PMID31840521
PMCPMC7944582
OpenAlexW2995868442

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.